{"id":"W4292265039","doi":"10.3390/metabo12080749","title":"Drug-Initiated Activity Metabolomics Identifies Myristoylglycine as a Potent Endogenous Metabolite for Human Brown Fat Differentiation","year":2022,"lang":"en","type":"article","venue":"Metabolites","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; National Cancer Institute; National Institute on Drug Abuse; National Institute of General Medical Sciences; National Institute of Mental Health; Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona","keywords":"Metabolomics; Metabolite; Drug; Metabolite profiling; Endogeny; Pharmacology; Biology; Bioinformatics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008986362,0.0006399551,0.001596165,0.0006637417,0.001281452,0.0001207807,0.0004032597,0.0001255244,0.0008398731],"category_scores_gemma":[0.000363117,0.0006021461,0.0007687935,0.0007539649,0.0001468877,0.0003791714,0.0003487591,0.0006026659,0.00006700426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001381242,"about_ca_system_score_gemma":0.0001575295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006366062,"about_ca_topic_score_gemma":0.00002687527,"domain_scores_codex":[0.9957635,0.0004682858,0.0008493906,0.0009619204,0.0009795738,0.0009773371],"domain_scores_gemma":[0.9975047,0.0002212331,0.000524395,0.0009511962,0.0004134215,0.0003850662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008920801,0.001261803,0.0014333,0.0001951328,0.00127814,0.00006763016,0.001938437,0.000027667,0.9645134,0.01619857,0.001070533,0.01112332],"study_design_scores_gemma":[0.007440284,0.0003800034,0.03985683,0.00002214522,0.005773488,0.0003254623,0.000895951,0.0001630258,0.6565477,0.007542993,0.2801639,0.000888153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9642013,0.02763815,0.0009073979,0.0007880776,0.001503158,0.002406523,0.0006637743,0.0003913799,0.001500268],"genre_scores_gemma":[0.9817129,0.000575073,0.0009565975,0.0008821588,0.0009405278,0.001114129,0.001351148,0.0001559972,0.01231149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3079657,"threshold_uncertainty_score":0.999643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05441345217441267,"score_gpt":0.3003272591169015,"score_spread":0.2459138069424888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}