{"id":"W4292265616","doi":"10.1200/po.22.00107","title":"Clinical Activity of Mitogen-Activated Protein Kinase–Targeted Therapies in Patients With Non–V600 BRAF-Mutant Tumors","year":2022,"lang":"en","type":"review","venue":"JCO Precision Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McGill University Health Centre; University of Toronto; University Health Network; McGill University; Jewish General Hospital","funders":"National Cancer Institute; Fonds de Recherche du Québec - Santé; Association Neurofibromatoses et Recklinghause; American Society of Clinical Oncology; Conquer Cancer Foundation","keywords":"Medicine; MAPK/ERK pathway; Lung cancer; Melanoma; Targeted therapy; Oncology; Cancer; Cancer research; Internal medicine; Protein kinase A; Mutant; Kinase; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007046282,0.0008933721,0.005164736,0.002714483,0.0002388175,0.001524948,0.0008078834,0.0009525148,0.001283861],"category_scores_gemma":[0.01725532,0.000562157,0.01527156,0.002984865,0.0003363012,0.00089929,0.0004799828,0.0009045217,0.0001221783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001067678,"about_ca_system_score_gemma":0.0008893209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00190744,"about_ca_topic_score_gemma":0.004794127,"domain_scores_codex":[0.9949067,0.002410118,0.001530925,0.0005382863,0.0005044767,0.0001093594],"domain_scores_gemma":[0.9821442,0.01342692,0.003260035,0.0003393485,0.0006905892,0.0001389423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00614062,0.00005660329,0.03494213,0.2804461,0.6286482,0.0001459472,0.0001271283,0.001244128,0.0008602088,0.0001817774,0.00116932,0.04603783],"study_design_scores_gemma":[0.001366996,0.001068379,0.04507586,0.03147972,0.9143351,0.000360484,0.0001164777,0.0005082412,0.00069225,0.0003696949,0.004586288,0.00004049988],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01734588,0.9812383,0.0002103771,0.0001808491,0.00007344797,0.00007135889,0.000424134,0.00001061155,0.0004450443],"genre_scores_gemma":[0.5890654,0.407667,0.0009531489,0.000802501,0.0002745611,0.0002297738,0.0007689681,0.00001670907,0.0002219273],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007046282,"threshold_uncertainty_score":0.03726476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03845418338333242,"score_gpt":0.3425475210552469,"score_spread":0.3040933376719145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}