{"id":"W4292265616","doi":"10.1200/po.22.00107","title":"Clinical Activity of Mitogen-Activated Protein Kinase–Targeted Therapies in Patients With Non–V600 BRAF-Mutant Tumors","year":2022,"lang":"en","type":"review","venue":"JCO Precision Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McGill University Health Centre; University of Toronto; University Health Network; McGill University; Jewish General Hospital","funders":"National Cancer Institute; Fonds de Recherche du Québec - Santé; Association Neurofibromatoses et Recklinghause; American Society of Clinical Oncology; Conquer Cancer Foundation","keywords":"Medicine; MAPK/ERK pathway; Lung cancer; Melanoma; Targeted therapy; Oncology; Cancer; Cancer research; Internal medicine; Protein kinase A; Mutant; Kinase; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008307621,0.0005256865,0.002150259,0.0002326637,0.00007508348,0.00001007106,0.0005910437,0.0009348075,0.0002540661],"category_scores_gemma":[0.0003626975,0.0003891482,0.0004559353,0.0003695785,0.000173509,0.000007704073,0.0004979449,0.0007544455,0.0000099852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001536517,"about_ca_system_score_gemma":0.001235788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003675216,"about_ca_topic_score_gemma":0.00004922195,"domain_scores_codex":[0.9955388,0.001541092,0.001166099,0.0009875544,0.0003467664,0.0004196369],"domain_scores_gemma":[0.9975092,0.0002170893,0.001172537,0.000850408,0.0001174513,0.0001333009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001286652,0.001402055,0.0007326395,0.0007729828,0.0002609952,0.00004013332,0.00004273926,0.000001181792,0.00984612,0.000003960543,0.0002142344,0.9853963],"study_design_scores_gemma":[0.002401963,0.007224209,0.002502152,0.0009413943,0.000112461,0.0000114099,0.00001412427,0.00000116082,0.005741089,0.000009401582,0.9805688,0.0004718227],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6796237,0.3156742,0.00004919231,0.0000116185,0.0007015339,0.003209567,0.0002450903,0.00001928388,0.0004657728],"genre_scores_gemma":[0.09634086,0.8994677,0.0007830734,0.000064584,0.0002708588,0.001016721,0.0014228,0.000172727,0.0004606835],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.9849245,"threshold_uncertainty_score":0.9998561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03845418338333242,"score_gpt":0.3425475210552469,"score_spread":0.3040933376719145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}