{"id":"W4292299706","doi":"10.1186/s12977-022-00605-4","title":"Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency","year":2022,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Canada Research Chairs; Canadian Blood Services; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Penn State College of Medicine; National Institutes of Health; Pennsylvania State University; Canadian Foundation for AIDS Research; University of Pennsylvania; GlaxoSmithKline","keywords":"Kinase; Human immunodeficiency virus (HIV); Gene expression; Gene; Latency (audio); Computational biology; Medicine; Gene expression profiling; Bioinformatics; Genetics; Biology; Cancer research; Virology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002047479,0.0003137498,0.0003408728,0.0002314713,0.0001420774,0.0004865509,0.0002687938,0.000227552,0.001231857],"category_scores_gemma":[0.0001476771,0.0001314391,0.0002158881,0.0001891533,0.000196011,0.0002659218,0.0002006465,0.0005496913,0.0002886676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000497355,"about_ca_system_score_gemma":0.0002986757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004893414,"about_ca_topic_score_gemma":0.0009530408,"domain_scores_codex":[0.9998745,0.00001558683,0.00001342158,0.00002895193,0.00003531367,0.00003227537],"domain_scores_gemma":[0.9999141,0.00001880134,0.00002872319,0.000007798466,0.000014441,0.00001623258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002428317,0.00003424121,0.0005430508,0.0001178382,0.000009910776,0.00005027054,0.00001073233,0.0003480275,0.9954756,0.0002597099,0.00005563959,0.002852231],"study_design_scores_gemma":[0.00007634261,0.0004571755,0.007003305,0.00001450876,0.00003802193,0.0002777223,0.00004430494,0.002589474,0.9861632,0.0001115318,0.003213073,0.00001139174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896197,0.005133682,0.002400146,0.0001860649,0.00002431681,0.00004473609,0.0004771367,0.00008575116,0.002028477],"genre_scores_gemma":[0.994715,0.001698736,0.001671532,0.00007467113,0.000007117152,0.00003317292,0.0003197917,0.00001051905,0.001469469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001231857,"threshold_uncertainty_score":0.004120946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01261317645161441,"score_gpt":0.2444831341733349,"score_spread":0.2318699577217205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}