{"id":"W4292299706","doi":"10.1186/s12977-022-00605-4","title":"Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency","year":2022,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Canada Research Chairs; Canadian Blood Services; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Penn State College of Medicine; National Institutes of Health; Pennsylvania State University; Canadian Foundation for AIDS Research; University of Pennsylvania; GlaxoSmithKline","keywords":"Kinase; Human immunodeficiency virus (HIV); Gene expression; Gene; Latency (audio); Computational biology; Medicine; Gene expression profiling; Bioinformatics; Genetics; Biology; Cancer research; Virology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002308642,0.00009822095,0.0002861133,0.0001815675,0.0001587055,0.00000292451,0.0001104871,0.00009638743,0.000426428],"category_scores_gemma":[0.00005439153,0.0000868467,0.00004026569,0.00008002028,0.0001557437,0.00003219696,0.0001891477,0.0002743842,0.00003076056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004135966,"about_ca_system_score_gemma":0.00004034097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000561465,"about_ca_topic_score_gemma":0.00002339104,"domain_scores_codex":[0.9987451,0.0004485875,0.0002192939,0.0002343193,0.00003652305,0.0003161147],"domain_scores_gemma":[0.9995432,0.0001945513,0.00007753065,0.0001489545,0.00001473352,0.00002103079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005876483,0.0001542136,0.107279,0.000008473289,0.00004296915,0.00005926185,0.0002487518,0.00007630075,0.8885663,0.0001148334,0.0001365214,0.002725821],"study_design_scores_gemma":[0.02055924,0.005262801,0.1191018,0.00005532854,0.00009707324,0.000594628,0.001215711,0.0001220791,0.8340603,0.0008285157,0.01761547,0.0004870961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871266,0.01196883,0.00003621314,0.00027193,0.0000839103,0.0001632737,0.0001052599,0.00001525352,0.0002287513],"genre_scores_gemma":[0.9990601,0.0003537567,0.00008175988,0.00005082961,0.000008783652,0.00004786312,0.0001414209,0.000008634718,0.0002468755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.054506,"threshold_uncertainty_score":0.4669088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01261317645161441,"score_gpt":0.2444831341733349,"score_spread":0.2318699577217205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}