{"id":"W4292315592","doi":"10.1002/cmdc.202100622","title":"Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against <i>Schistosoma mansoni</i>","year":2022,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Schistosoma mansoni; HDAC8; Histone deacetylase; Schistosomiasis; Biology; IC50; Praziquantel; Potency; Schistosoma; Pharmacology; Immunology; Histone; Biochemistry; In vitro; Gene; Helminths","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001237298,0.0004549497,0.0002649988,0.0002231679,0.0001059985,0.000134341,0.0001902329,0.0001565768,0.001459293],"category_scores_gemma":[0.00009919935,0.000108671,0.0001943462,0.000225529,0.00009955993,0.0000907908,0.0001292657,0.0002487535,0.0003596327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772643,"about_ca_system_score_gemma":0.0001789345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006544583,"about_ca_topic_score_gemma":0.001803348,"domain_scores_codex":[0.9999216,0.0000169651,0.000008129377,0.00001511064,0.00002096003,0.00001724623],"domain_scores_gemma":[0.9999458,0.0000102088,0.00001098327,0.000004522054,0.00001380963,0.00001469738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001093331,0.00007092788,0.0001794007,0.00007849009,0.000007634714,0.0000314948,0.000006663956,0.0001290085,0.9961807,0.00002733069,0.00009917915,0.003079934],"study_design_scores_gemma":[0.00005755234,0.002687343,0.004615929,0.00001146603,0.00004612731,0.0002238126,0.00001942159,0.0005359153,0.9888831,0.00001741281,0.002895843,0.00000619741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869538,0.003725111,0.003422693,0.0001539962,0.00003546915,0.0001896342,0.001263403,0.0001450118,0.004110917],"genre_scores_gemma":[0.9865187,0.003417636,0.004084995,0.0001100219,0.00001950247,0.0001083173,0.002238336,0.00002001392,0.003482448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459293,"threshold_uncertainty_score":0.004881859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01515622012861871,"score_gpt":0.2834207829450182,"score_spread":0.2682645628163995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}