{"id":"W4292315592","doi":"10.1002/cmdc.202100622","title":"Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against <i>Schistosoma mansoni</i>","year":2022,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Schistosoma mansoni; HDAC8; Histone deacetylase; Schistosomiasis; Biology; IC50; Praziquantel; Potency; Schistosoma; Pharmacology; Immunology; Histone; Biochemistry; In vitro; Gene; Helminths","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001379253,0.0001754277,0.0002881002,0.0001210019,0.0004167223,0.000005144243,0.0002670483,0.0000976683,0.001565755],"category_scores_gemma":[0.0000417796,0.0001930767,0.0001781839,0.0002074796,0.0001732994,0.00007261131,0.000208368,0.000525906,0.0001542379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001364586,"about_ca_system_score_gemma":0.00006095188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001210705,"about_ca_topic_score_gemma":0.00001249265,"domain_scores_codex":[0.9988942,0.00007289054,0.0003522432,0.0002892285,0.00006334273,0.000328087],"domain_scores_gemma":[0.9992865,0.00009450178,0.0002149126,0.0003222791,0.00004744389,0.00003433436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000145071,0.00026293,0.0008183774,0.00001819652,0.0001209383,0.000008334516,0.0006522481,0.00005552877,0.9522751,0.0003385454,0.0379364,0.007368305],"study_design_scores_gemma":[0.0007900071,0.00007511322,0.0006927755,0.00001510859,0.00003567285,0.00005660943,0.0005972833,0.000007533523,0.7782137,0.00002856763,0.2193208,0.0001668786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798186,0.004080086,0.0001193313,0.0004246489,0.000863765,0.000144194,0.0000871929,0.00009024245,0.01437192],"genre_scores_gemma":[0.9907418,0.00002871503,0.0002423918,0.000416159,0.00004941386,0.00006425231,0.0002202038,0.00002719762,0.008209795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1813844,"threshold_uncertainty_score":0.999347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01515622012861871,"score_gpt":0.2834207829450182,"score_spread":0.2682645628163995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}