{"id":"W4292322519","doi":"10.1016/j.parkreldis.2022.08.002","title":"Motor and nonmotor symptoms in patients treated with 24-hour daily levodopa-carbidopa intestinal gel infusion: Analysis of the COmedication Study assessing Mono- and cOmbination therapy with levodopa-carbidopa inteStinal gel (COSMOS)","year":2022,"lang":"en","type":"article","venue":"Parkinsonism & Related Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; Krembil Foundation; University of Toronto","funders":"National Research, Development and Innovation Office; Sanofi Genzyme; Ipsen; H. Lundbeck A/S; UCB; Boston Scientific Corporation; Sunovion; Allergan; Medtronic; Teva Pharmaceutical Industries; Novartis; Parkinson's Foundation; Pfizer; Pécsi Tudományegyetem; Chiesi Farmaceutici; EVER Neuro Pharma; University of Toronto; AbbVie; Abbott Laboratories; Sanofi; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Michael J. Fox Foundation for Parkinson's Research","keywords":"Dyskinesia; Medicine; Parkinson's disease; Levodopa; Carbidopa; Adverse effect; Internal medicine; Physical therapy; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001272126,0.0004650473,0.001271898,0.0008913411,0.0004111426,0.0005112572,0.000324017,0.0005729847,0.001091295],"category_scores_gemma":[0.003098305,0.0002487392,0.00121572,0.0008163906,0.0002759116,0.000484853,0.0004778213,0.0004827922,0.0001173015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005005324,"about_ca_system_score_gemma":0.0003522614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001832131,"about_ca_topic_score_gemma":0.00284609,"domain_scores_codex":[0.9993249,0.0002675311,0.0001046514,0.00009061736,0.0001440909,0.00006820849],"domain_scores_gemma":[0.9973812,0.0007714811,0.00101649,0.00008344214,0.0002196603,0.0005278521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02044469,0.0006369409,0.9701551,0.00009678972,0.0006628942,0.0003217039,0.0001493864,0.0001011608,0.001352694,0.00002325471,0.00009323734,0.005962058],"study_design_scores_gemma":[0.0005686142,0.004496393,0.9936283,0.00000851627,0.0002181204,0.00049988,0.0001026015,0.0002166305,0.0001227721,0.00001193951,0.0001165509,0.000009741043],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991854,0.0004159579,0.00002905671,0.00001091282,0.000003514567,0.00002230687,0.0001125723,0.00000208821,0.000218089],"genre_scores_gemma":[0.9992744,0.0001439427,0.0000829971,0.00003501659,0.000008619372,0.00002141072,0.0003223292,0.000001775779,0.0001094501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001832131,"threshold_uncertainty_score":0.006727755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00931024333883203,"score_gpt":0.2344433248651567,"score_spread":0.2251330815263246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}