{"id":"W4292367025","doi":"10.1001/jamahealthforum.2022.2685","title":"Therapeutic Value of Drugs Granted Accelerated Approval or Conditional Marketing Authorization in the US and Europe From 2007 to 2021","year":2022,"lang":"en","type":"article","venue":"JAMA Health Forum","topic":"Pharmaceutical Economics and Policy","field":"Economics, Econometrics and Finance","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Arnold Ventures; Swiss Cancer Research Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Kaiser Permanente; National Science Foundation","keywords":"Marketing authorization; Medicine; Authorization; European union; Agency (philosophy); Value (mathematics); Cohort; Drug; Family medicine; Business; Pharmacology; Internal medicine; Bioinformatics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002035087,0.0001018093,0.0002778328,0.0001780705,0.0002308108,0.00005511193,0.0002046623,0.00003811215,0.001242721],"category_scores_gemma":[0.0001227382,0.00009633903,0.00003368718,0.000479004,0.00002939451,0.0001014952,0.0001085058,0.0002653115,0.00003544858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001057072,"about_ca_system_score_gemma":0.0001047611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009090654,"about_ca_topic_score_gemma":0.00004373578,"domain_scores_codex":[0.9985093,0.0002000314,0.0006385908,0.0002823835,0.00004899735,0.0003207114],"domain_scores_gemma":[0.9991671,0.000288588,0.0002849451,0.0001475194,0.00001954383,0.00009227493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001604618,0.0005386429,0.08294333,0.0001604114,0.0001225524,0.000009202466,0.005473857,0.003414135,0.00008091373,0.8405127,0.02881338,0.03632627],"study_design_scores_gemma":[0.00243345,0.0003117616,0.284912,0.00002366733,0.000005915416,0.000008199396,0.000950081,0.09609385,0.00002074543,0.02916866,0.5857642,0.0003074332],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9060317,0.001919635,0.001077987,0.07933831,0.0005814165,0.000950184,0.003042704,0.00001597822,0.007042099],"genre_scores_gemma":[0.9710206,0.0003047771,0.0001596795,0.0280157,0.0001020803,0.00005948839,0.0001994061,0.0000176298,0.0001206075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.811344,"threshold_uncertainty_score":0.9996703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05984786430854934,"score_gpt":0.3167756284411808,"score_spread":0.2569277641326315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}