{"id":"W4292367479","doi":"10.1038/s41401-022-00965-9","title":"Sustained over-expression of calpain-2 induces age-dependent dilated cardiomyopathy in mice through aberrant autophagy","year":2022,"lang":"en","type":"article","venue":"Acta Pharmacologica Sinica","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; National Heart, Lung, and Blood Institute; Government of Jiangsu Province","keywords":"Calpain; Autophagy; Genetically modified mouse; Cardiomyopathy; Transgene; Dilated cardiomyopathy; Internal medicine; Cardiac function curve; Endocrinology; Myocyte; Heart failure; Medicine; Biology; Apoptosis; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003523076,0.000766192,0.000576598,0.0007687327,0.0002825096,0.0004859672,0.0003982025,0.0008602319,0.001615507],"category_scores_gemma":[0.0001612087,0.0004519275,0.0005782292,0.0003222721,0.0006071847,0.0005132094,0.0002841604,0.001534385,0.0004263036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004925553,"about_ca_system_score_gemma":0.0003453225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004340713,"about_ca_topic_score_gemma":0.001048979,"domain_scores_codex":[0.9997067,0.00004075233,0.00003615755,0.00007783123,0.00005424208,0.00008431758],"domain_scores_gemma":[0.999648,0.00003403492,0.0001492813,0.0000330551,0.00001701736,0.000118578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005206947,0.0000977591,0.0001550208,0.00002849269,0.000009381808,0.0001579493,0.00001568136,0.00004241926,0.9980872,0.0001661726,0.00004735813,0.0006717763],"study_design_scores_gemma":[0.0002219982,0.001068336,0.007472699,0.00002095925,0.00006603652,0.000738783,0.00007580315,0.001335487,0.9867135,0.0002584076,0.002012085,0.00001595542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905027,0.002161377,0.004083692,0.0004179185,0.0001468929,0.00007434457,0.0007835322,0.0003088946,0.00152061],"genre_scores_gemma":[0.9896125,0.001376068,0.00267405,0.0001924435,0.00005009963,0.000137058,0.0005735627,0.00008410642,0.00530003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001615507,"threshold_uncertainty_score":0.005404353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01777901886370072,"score_gpt":0.2888498701233546,"score_spread":0.2710708512596539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}