{"id":"W4292371797","doi":"10.1038/s41467-022-32376-z","title":"SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; National Institutes of Health; Michael Smith Health Research BC; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Weill Cornell Medical College","keywords":"Granzyme B; Cytotoxic T cell; CD8; Granzyme; Immunology; HIV vaccine; Virology; Biology; Immune system; Granzyme A; Vaccination; T cell; Effector; Perforin; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009312764,0.000258418,0.0002032009,0.0001040217,0.00008741293,0.0002219448,0.0000804009,0.0002227975,0.002607726],"category_scores_gemma":[0.0001166476,0.00007590657,0.0001329585,0.00004139133,0.0001074932,0.000147279,0.0001286739,0.0006764734,0.0005524315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001106151,"about_ca_system_score_gemma":0.00009417121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000129423,"about_ca_topic_score_gemma":0.0001550232,"domain_scores_codex":[0.9998927,0.00001846334,0.0000101057,0.00002682485,0.00001854775,0.00003326187],"domain_scores_gemma":[0.9999316,0.00001517268,0.00001188593,0.00001200259,0.00001089201,0.000018489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002457624,0.00007950359,0.0003027669,0.00002617126,0.000002090998,0.00001714933,0.00001401187,0.00003659508,0.9973851,0.00002884137,0.00002834866,0.001833582],"study_design_scores_gemma":[0.00006169698,0.00345967,0.008881994,0.00001135934,0.00001701501,0.000303156,0.00007049317,0.00141585,0.9838113,0.000099814,0.001863314,0.000004374919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968151,0.0003898786,0.001191695,0.00003978996,0.00003041384,0.00004671055,0.0001682981,0.00006971836,0.00124834],"genre_scores_gemma":[0.9971621,0.0001230239,0.0007712384,0.000050857,0.00001744627,0.00004163057,0.0001977507,0.00001136787,0.001624506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002607726,"threshold_uncertainty_score":0.008723736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03835474271199078,"score_gpt":0.3144998632305412,"score_spread":0.2761451205185504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}