{"id":"W4292373099","doi":"10.3389/fphys.2022.886807","title":"Sickle cell cerebrovascular reactivity to a CO2 stimulus: Too little, too slow","year":2022,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Public Health Ontario; University of Toronto; Centre Hospitalier de l’Université de Montréal; University Health Network","funders":"National Heart, Lung, and Blood Institute; University of Toronto; Apellis Pharmaceuticals; Agios Pharmaceuticals; National Institutes of Health; Thalassemia Foundation of Canada; Cincinnati Children's Hospital Medical Center; Celgene; Alexion Pharmaceuticals; Pfizer","keywords":"Cerebral blood flow; Medicine; Cardiology; White matter; Magnetic resonance imaging; Vasodilation; Hematocrit; Internal medicine; Sickle cell anemia; Anesthesia; Disease; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002960895,0.0001898964,0.0002524297,0.000500082,0.000250028,0.0003081391,0.000106351,0.0002113444,0.0006998155],"category_scores_gemma":[0.0006280892,0.00007854403,0.0001359092,0.0002842666,0.0004007975,0.0001535609,0.0001564601,0.0001228721,0.00008668941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002242799,"about_ca_system_score_gemma":0.0001704895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000629389,"about_ca_topic_score_gemma":0.0009786022,"domain_scores_codex":[0.999899,0.00001816906,0.00001838375,0.00002688728,0.00002191857,0.00001567466],"domain_scores_gemma":[0.9994654,0.0001028092,0.0002944185,0.00002698992,0.00005502857,0.00005538194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001131082,0.00003083343,0.9671709,0.00009192319,0.00009428508,0.003059969,0.0002861765,0.0002392821,0.01646268,0.0001124697,0.0002447494,0.01107557],"study_design_scores_gemma":[0.00001341978,0.0002881889,0.9842566,0.0000153452,0.00007083405,0.01161661,0.0001061211,0.0003765621,0.002541525,0.0001724726,0.0005317547,0.00001066159],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994032,0.000207141,0.0001449707,0.00001502613,0.00000288257,0.000004347722,0.00007045883,0.000003451182,0.0001486116],"genre_scores_gemma":[0.999737,0.00007187531,0.00007676074,0.00001269956,0.00001099464,0.00000228277,0.00005716453,0.000001069594,0.0000301121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006998155,"threshold_uncertainty_score":0.002341151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005716629416024904,"score_gpt":0.2170891791256475,"score_spread":0.2113725497096226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}