{"id":"W4292373099","doi":"10.3389/fphys.2022.886807","title":"Sickle cell cerebrovascular reactivity to a CO2 stimulus: Too little, too slow","year":2022,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Public Health Ontario; University of Toronto; Centre Hospitalier de l’Université de Montréal; University Health Network","funders":"National Heart, Lung, and Blood Institute; University of Toronto; Apellis Pharmaceuticals; Agios Pharmaceuticals; National Institutes of Health; Thalassemia Foundation of Canada; Cincinnati Children's Hospital Medical Center; Celgene; Alexion Pharmaceuticals; Pfizer","keywords":"Cerebral blood flow; Medicine; Cardiology; White matter; Magnetic resonance imaging; Vasodilation; Hematocrit; Internal medicine; Sickle cell anemia; Anesthesia; Disease; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002480475,0.0002115544,0.0005822717,0.0002316937,0.0001588198,0.00000616942,0.0002069091,0.0001549499,0.0002108162],"category_scores_gemma":[0.00007831283,0.0002028434,0.0001862604,0.0005625514,0.0001031461,0.00005296808,0.0002532315,0.000684795,0.00005553191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002858822,"about_ca_system_score_gemma":0.0001566163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002388836,"about_ca_topic_score_gemma":0.00000316237,"domain_scores_codex":[0.998203,0.0002142048,0.0002821255,0.0005303023,0.0002396717,0.0005306784],"domain_scores_gemma":[0.9991515,0.00004240581,0.00006993588,0.0005280593,0.00003818672,0.0001699467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001788284,0.002095519,0.01720061,0.0002147658,0.0002807442,0.000170852,0.002942665,0.0101918,0.0937133,0.0001211252,0.8550745,0.01620585],"study_design_scores_gemma":[0.009564715,0.003211306,0.08063325,0.00005887508,0.0002560941,0.000082508,0.008800209,0.00615793,0.005747313,0.002743568,0.8817369,0.001007391],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872991,0.001123485,0.0007475742,0.001788961,0.001820332,0.0007185509,0.00002691206,0.00008430069,0.006390826],"genre_scores_gemma":[0.9890534,0.0001541248,0.00257313,0.0034004,0.0001035495,0.0001408075,0.00008622911,0.00004206778,0.00444626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08796599,"threshold_uncertainty_score":0.8271711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005716629416024904,"score_gpt":0.2170891791256475,"score_spread":0.2113725497096226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}