{"id":"W4292373353","doi":"10.3390/insects13080745","title":"Pyrethroids in an AlphaFold2 Model of the Insect Sodium Channel","year":2022,"lang":"en","type":"article","venue":"Insects","topic":"Insect and Pesticide Research","field":"Agricultural and Biological Sciences","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Russian Science Foundation","keywords":"Pyrethroid; Knockdown resistance; Deltamethrin; Sodium channel; Biology; Allosteric regulation; Homology modeling; Biophysics; Genetics; Computational biology; Receptor; Biochemistry; Sodium; Pesticide; Chemistry; Cyfluthrin; Enzyme; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004192472,0.00008520767,0.000121807,0.00002232679,0.0002633059,0.00001700877,0.0005217987,0.00004500923,0.0005027829],"category_scores_gemma":[0.00003002494,0.00003063122,0.00006595231,0.0005656787,0.00006474248,0.00007568087,0.0002684922,0.000285591,0.000003291392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004261273,"about_ca_system_score_gemma":0.00004036424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001646542,"about_ca_topic_score_gemma":0.002845467,"domain_scores_codex":[0.9987903,0.0002187327,0.0001595552,0.000182052,0.0003716329,0.0002776763],"domain_scores_gemma":[0.9996673,0.0001058599,0.00004880723,0.00008875184,0.00003901558,0.00005023972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001420159,0.0003683423,0.01848134,0.00001401423,0.000005961899,0.000009930486,0.001779558,0.004662481,0.9658271,0.00108193,0.0003447191,0.00728262],"study_design_scores_gemma":[0.001020488,0.002522941,0.7331342,0.00003937589,0.00001386959,0.00002957359,0.001491932,0.1356876,0.08312513,0.04103534,0.001208854,0.0006907326],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973956,0.00008375733,6.936783e-7,0.0005369253,0.000122883,0.0001920924,0.00004296086,0.00001837966,0.001606647],"genre_scores_gemma":[0.9993776,0.000007827152,0.000006121225,0.0002964922,0.0000748235,0.00004190944,0.00001228353,0.000001131433,0.0001818251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8827019,"threshold_uncertainty_score":0.5505121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08570494807413784,"score_gpt":0.2643065133946879,"score_spread":0.17860156532055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}