{"id":"W4292373353","doi":"10.3390/insects13080745","title":"Pyrethroids in an AlphaFold2 Model of the Insect Sodium Channel","year":2022,"lang":"en","type":"article","venue":"Insects","topic":"Insect and Pesticide Research","field":"Agricultural and Biological Sciences","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Russian Science Foundation","keywords":"Pyrethroid; Knockdown resistance; Deltamethrin; Sodium channel; Biology; Allosteric regulation; Homology modeling; Biophysics; Genetics; Computational biology; Receptor; Biochemistry; Sodium; Pesticide; Chemistry; Cyfluthrin; Enzyme; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000139212,0.0003438786,0.0004099628,0.0001921174,0.0003763823,0.0004611415,0.0005971908,0.0009628284,0.003431909],"category_scores_gemma":[0.0003062898,0.0001883373,0.0005342726,0.0001965369,0.0003188976,0.0004469073,0.000318591,0.0003231668,0.0002373703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006834281,"about_ca_system_score_gemma":0.000805294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01676901,"about_ca_topic_score_gemma":0.008221501,"domain_scores_codex":[0.9999518,0.00001495212,0.000002229125,0.00001039695,0.0000107438,0.000009770296],"domain_scores_gemma":[0.9999123,0.0000342496,0.00001047706,0.000005075643,0.00002385621,0.00001410694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00005436075,0.00001541914,0.0003527594,0.00002443991,0.000009095916,0.00009645359,0.00001848551,0.9936252,0.001219932,0.003230659,0.0002321423,0.00112114],"study_design_scores_gemma":[0.000009591876,0.000009771456,0.00008604906,0.000001532004,0.00000151561,0.00000680696,0.000004093493,0.9990783,0.00006436583,0.0005862658,0.0001501587,0.000001555183],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8516824,0.0007915691,0.1030023,0.0008601407,0.0001190852,0.00006281714,0.001041456,0.0005132803,0.04192675],"genre_scores_gemma":[0.9835344,0.0002232564,0.009440105,0.00007196842,0.00001576507,0.00007489187,0.0003819677,0.0000380348,0.006219724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01676901,"threshold_uncertainty_score":0.03334284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08570494807413784,"score_gpt":0.2643065133946879,"score_spread":0.17860156532055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}