{"id":"W4292378839","doi":"10.1039/d2cc03967b","title":"Probing metal-dependent G-quadruplexes using the intrinsic fluorescence of DNA","year":2022,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Fluorescence; G-quadruplex; DNA; Chemistry; Kinetics; Metal; Biophysics; Biology; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003095295,0.0004585469,0.0003257733,0.0002808282,0.0002320001,0.0003602317,0.000432497,0.0005828325,0.001043704],"category_scores_gemma":[0.0009044562,0.0002250693,0.0001817129,0.000190104,0.0004635862,0.0003799164,0.000267467,0.0007952485,0.0004251751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005433508,"about_ca_system_score_gemma":0.0002799141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008150098,"about_ca_topic_score_gemma":0.001095998,"domain_scores_codex":[0.9997073,0.0000564911,0.00001047481,0.0001223344,0.00005712381,0.00004625251],"domain_scores_gemma":[0.9996686,0.0001420754,0.00004860217,0.00002744287,0.00005627958,0.000056989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001868355,0.000004061885,0.00006181576,0.00002196559,0.000002620702,0.00000899171,0.00002211512,0.00006142948,0.9992135,0.00004636229,0.000007469818,0.0005309968],"study_design_scores_gemma":[0.000004885715,0.00006891352,0.0004381377,0.000003427313,0.000003572816,0.00006956796,0.000009901751,0.0009759109,0.9979723,0.00005060299,0.0003966528,0.000006121779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.964478,0.001165351,0.03204349,0.0001571628,0.00002778422,0.00004567642,0.0002780246,0.0002793749,0.001525156],"genre_scores_gemma":[0.9719919,0.0005936277,0.02506025,0.00008059531,0.0000106793,0.0000482902,0.0003667524,0.00003898647,0.001808947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001043704,"threshold_uncertainty_score":0.00394237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03142391749537947,"score_gpt":0.3046237770759728,"score_spread":0.2731998595805933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}