{"id":"W4292385829","doi":"10.1371/journal.pcbi.1010413","title":"Mitochondrial mRNA localization is governed by translation kinetics and spatial transport","year":2022,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Research Corporation for Science Advancement; National Science Foundation","keywords":"Messenger RNA; Mitochondrion; Translation (biology); Biology; Cell biology; P-bodies; Ribosome; Cytosol; Poly(A)-binding protein; Gene expression; Gene; Molecular biology; Genetics; Biochemistry; RNA; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005944053,0.0001163043,0.00011785,0.00003019301,0.0001444065,0.000007230854,0.00009647349,0.00009857791,0.0002029324],"category_scores_gemma":[0.0000129285,0.000126456,0.00004451514,0.00005533229,0.00005296523,0.000002795221,0.00003295191,0.00005879509,0.000002961813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001323915,"about_ca_system_score_gemma":0.00003378899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002866314,"about_ca_topic_score_gemma":0.000008782269,"domain_scores_codex":[0.9990885,0.0001221683,0.0001993469,0.0003150155,0.0001427457,0.0001322303],"domain_scores_gemma":[0.9997165,0.00003011972,0.0000800178,0.0000868033,0.00004255062,0.00004404521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002458964,0.0001173824,0.001099334,0.000009337946,0.00006076305,8.190954e-7,0.00009346553,0.002490033,0.9862514,0.0002618785,0.0007285484,0.008641134],"study_design_scores_gemma":[0.003711096,0.003149854,0.001601098,0.00001006889,0.0001203438,0.00005185319,0.0000805657,0.04206364,0.7347643,0.01304073,0.2005305,0.00087599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3988822,0.0008481687,0.5976859,0.0008888491,0.0002943601,0.0004177005,0.0006686198,0.00002444009,0.0002898338],"genre_scores_gemma":[0.9933867,0.00003519706,0.002947503,0.0007511075,0.000153087,0.00005763045,0.002568502,0.00001697285,0.00008330489],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5947384,"threshold_uncertainty_score":0.5156724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01204991802185119,"score_gpt":0.2242723862961357,"score_spread":0.2122224682742846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}