{"id":"W4292425178","doi":"10.1016/j.isci.2022.104968","title":"Two types of human TCR differentially regulate reactivity to self and non-self antigens","year":2022,"lang":"en","type":"article","venue":"iScience","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Mila - Quebec Artificial Intelligence Institute; Institute for Research in Immunology and Cancer","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"T-cell receptor; Repertoire; Biology; Immunology; Antigen; Terminal deoxynucleotidyl transferase; Genetics; Cell biology; T cell; Immune system; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002833472,0.0001210427,0.0002326072,0.0001188243,0.0005482453,0.00001095048,0.0003695083,0.00005750551,0.0004051015],"category_scores_gemma":[0.00001306932,0.0001089733,0.00004223614,0.0002331901,0.0002753579,0.00006759377,0.0005421848,0.000213915,0.00005043103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002679461,"about_ca_system_score_gemma":0.00005168527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002895025,"about_ca_topic_score_gemma":0.00007057424,"domain_scores_codex":[0.9989387,0.0001420442,0.0001860213,0.0003638068,0.0000538384,0.0003155297],"domain_scores_gemma":[0.9994729,0.00005265846,0.0001042496,0.0003107176,0.00003628678,0.00002320877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003062789,0.0002184286,0.003026726,0.000006552789,0.00003210006,0.000004104583,0.001472031,0.000005734678,0.9927459,0.0006348858,0.0002776624,0.001545242],"study_design_scores_gemma":[0.0008739498,0.0007640509,0.0511701,0.000009129911,0.00003576226,0.00008187765,0.0002522935,0.00001587405,0.929887,0.0002823318,0.01639644,0.0002311985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969175,0.0005120864,0.00002877309,0.0001586874,0.000533881,0.0001602581,0.00001595143,0.0000601491,0.001612697],"genre_scores_gemma":[0.9977993,0.00002382462,0.0001339361,0.00007984909,0.00001084465,0.00001203021,0.000007713581,0.000007530684,0.001924984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0628589,"threshold_uncertainty_score":0.4443803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104220632317673,"score_gpt":0.2394343791671871,"score_spread":0.2290123159354198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}