{"id":"W4292451837","doi":"10.3390/nu14153221","title":"Vitamin D and Diseases of Mineral Homeostasis: A Cyp24a1 R396W Humanized Preclinical Model of Infantile Hypercalcemia Type 1","year":2022,"lang":"en","type":"article","venue":"Nutrients","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; McGill University; Shriners Hospitals for Children - Canada","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health","keywords":"CYP24A1; Mutant; Vitamin D and neurology; Mutation; Allele; Biology; Phenotype; Molecular biology; Internal medicine; Endocrinology; Medicine; Genetics; Gene; Calcitriol receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007026132,0.001125153,0.0009637479,0.001149241,0.0006466277,0.0006362946,0.000802293,0.001405993,0.003645916],"category_scores_gemma":[0.0003327238,0.0004818963,0.0006498146,0.0004904346,0.0007442682,0.0005263138,0.0004794375,0.002638981,0.0009232541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006528921,"about_ca_system_score_gemma":0.0005215048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007733997,"about_ca_topic_score_gemma":0.001045111,"domain_scores_codex":[0.9994276,0.0001219213,0.00005938343,0.0001465848,0.0001379537,0.0001064968],"domain_scores_gemma":[0.9994386,0.00006447938,0.0001412346,0.00008092626,0.00004718654,0.000227594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003390289,0.002978086,0.0007704588,0.0001420846,0.0000382557,0.001265227,0.000120638,0.0003705122,0.9841558,0.0009542439,0.0005686946,0.005245702],"study_design_scores_gemma":[0.001840256,0.03767341,0.01000971,0.0001012448,0.0002434752,0.009029988,0.0002874006,0.003472173,0.9120646,0.0008059252,0.02439288,0.00007894976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882386,0.002319145,0.004055763,0.0007491739,0.0001372921,0.0003258987,0.001856739,0.0002475649,0.002069856],"genre_scores_gemma":[0.9719067,0.0030493,0.008429889,0.0003560045,0.0001015413,0.0008598965,0.002864178,0.0001128324,0.01231975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003645916,"threshold_uncertainty_score":0.01219684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04464136219233333,"score_gpt":0.3423327496644208,"score_spread":0.2976913874720875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}