{"id":"W4292466798","doi":"10.3389/fonc.2022.969563","title":"Methionine cycle-dependent regulation of T cells in cancer immunity","year":2022,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research; Ovarian Cancer Canada; University of Victoria; U.S. Department of Defense","keywords":"Methionine; Cell cycle; Cell biology; Biology; Cancer cell; Reprogramming; Immune system; Effector; Immunotherapy; Tumor microenvironment; Cancer research; Cell; Cancer; Biochemistry; Immunology; Genetics; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004444422,0.0002003976,0.0009420587,0.0003100812,0.00003098091,0.00000361764,0.0003185701,0.0003728708,0.0002302003],"category_scores_gemma":[0.00005150057,0.0001938792,0.000182108,0.0002751369,0.00008448757,0.000002527918,0.0002698147,0.0004229506,0.000001768945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000946814,"about_ca_system_score_gemma":0.001015654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001945466,"about_ca_topic_score_gemma":0.002382274,"domain_scores_codex":[0.9980413,0.0006864426,0.0004699273,0.0003628676,0.0001588608,0.0002805693],"domain_scores_gemma":[0.9992572,0.00003921747,0.0002726195,0.000359152,0.00002267982,0.00004910394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001346629,0.0002942967,0.0002882048,0.000961542,0.000209304,0.00002429859,0.00003876987,0.0001108889,0.0001970424,0.000004194905,0.003231972,0.9945048],"study_design_scores_gemma":[0.000801987,0.0003484924,0.00006046603,0.0002531797,0.0000796595,0.00000597789,0.00003914598,0.00000756697,0.0004151463,0.00005943972,0.9977816,0.0001472913],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004828382,0.9969265,0.0000610749,0.00001742555,0.0007934489,0.000635234,0.0001657616,0.000002901633,0.0009147493],"genre_scores_gemma":[0.000356632,0.9972477,0.0005961374,0.00001464248,0.00006921582,0.0005637013,0.0005603696,0.00002918318,0.0005624016],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9945497,"threshold_uncertainty_score":0.7906163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04098972838932197,"score_gpt":0.3930255852624605,"score_spread":0.3520358568731385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}