{"id":"W4292470370","doi":"10.1007/s12325-022-02269-0","title":"The Effect of Guselkumab on General Health State in Biologic-Naïve Patients with Active Psoriatic Arthritis Through Week 52 of the Phase 3, Randomized, Placebo-Controlled DISCOVER-2 Trial","year":2022,"lang":"en","type":"article","venue":"Advances in Therapy","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; University of Toronto; Toronto Western Hospital; Memorial University of Newfoundland","funders":"Janssen Research and Development","keywords":"Medicine; Psoriatic arthritis; Placebo; Dermatology Life Quality Index; Visual analogue scale; Crossover study; Internal medicine; Quality of life (healthcare); EQ-5D; Physical therapy; Randomized controlled trial; Arthritis; Health related quality of life; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007147798,0.0002292927,0.001355745,0.00005659364,0.0002088486,0.00000520014,0.0001417827,0.00002209081,0.00001974117],"category_scores_gemma":[0.0001871367,0.00009883089,0.0002185334,0.0002845179,0.0002676332,0.00008871112,0.0000426757,0.0002241045,3.224601e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001787317,"about_ca_system_score_gemma":0.00008673548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003148786,"about_ca_topic_score_gemma":0.0003634544,"domain_scores_codex":[0.9970077,0.00141335,0.0006173045,0.0002606951,0.0004048386,0.0002961243],"domain_scores_gemma":[0.9973869,0.001671381,0.0005939924,0.0002924367,0.00003142832,0.00002385655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8133754,0.001188613,0.002367022,0.000009507425,0.0003108939,0.000005876341,0.001172875,0.0004423904,0.000005207762,0.00006872483,0.000007024772,0.1810465],"study_design_scores_gemma":[0.9645513,0.03190372,0.001016051,0.0001363742,0.0000312447,0.000001358782,0.0002391871,0.00001746047,0.0006899799,0.0008197716,0.0005056857,0.000087884],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737046,0.01735858,0.00001077247,0.0002639321,0.0005473886,0.007841071,0.0001397359,0.000007336085,0.0001265313],"genre_scores_gemma":[0.9784929,0.0194136,0.00004010002,0.0001528407,0.0000335199,0.001791687,0.00002546064,0.00001738728,0.00003248846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1809586,"threshold_uncertainty_score":0.4030207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007456155231777105,"score_gpt":0.3030588510880241,"score_spread":0.2956026958562469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}