{"id":"W4292470370","doi":"10.1007/s12325-022-02269-0","title":"The Effect of Guselkumab on General Health State in Biologic-Naïve Patients with Active Psoriatic Arthritis Through Week 52 of the Phase 3, Randomized, Placebo-Controlled DISCOVER-2 Trial","year":2022,"lang":"en","type":"article","venue":"Advances in Therapy","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; University of Toronto; Toronto Western Hospital; Memorial University of Newfoundland","funders":"Janssen Research and Development","keywords":"Medicine; Psoriatic arthritis; Placebo; Dermatology Life Quality Index; Visual analogue scale; Crossover study; Internal medicine; Quality of life (healthcare); EQ-5D; Physical therapy; Randomized controlled trial; Arthritis; Health related quality of life; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001263204,0.001568998,0.003654101,0.0003882485,0.0004819758,0.001038093,0.000834171,0.001605515,0.005443745],"category_scores_gemma":[0.001494073,0.0006657683,0.00221671,0.0003519568,0.001008588,0.001490603,0.0004711027,0.004248254,0.001090443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005987652,"about_ca_system_score_gemma":0.0007800002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001172605,"about_ca_topic_score_gemma":0.002955422,"domain_scores_codex":[0.9994878,0.0002412626,0.00002333484,0.00009401592,0.00003320186,0.0001203201],"domain_scores_gemma":[0.9992761,0.000211728,0.0001597224,0.00007010638,0.00003839619,0.0002439539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9793834,0.003442924,0.0009533673,0.0003660311,0.0007777893,0.0000310129,0.00004873823,0.0002978071,0.001777709,0.00006974709,0.0006125777,0.01223891],"study_design_scores_gemma":[0.9331803,0.05768755,0.006866372,0.00004230483,0.0006835879,0.00003314501,0.00003979226,0.0004655802,0.0003782951,0.0001974209,0.0004046267,0.0000208604],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919642,0.0034619,0.0003557584,0.0006191846,0.0003293527,0.0005686375,0.000841208,0.0001307003,0.001729017],"genre_scores_gemma":[0.9925029,0.001542269,0.0005768039,0.0007478509,0.0002518088,0.0008018817,0.0008988574,0.00002862161,0.002649078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005443745,"threshold_uncertainty_score":0.01821119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007456155231777105,"score_gpt":0.3030588510880241,"score_spread":0.2956026958562469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}