{"id":"W4292548452","doi":"10.3390/biomedicines10082024","title":"Tumor Temperature: Friend or Foe of Virus-Based Cancer Immunotherapy","year":2022,"lang":"en","type":"review","venue":"Biomedicines","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Redeemer University; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Cancer Research Society","keywords":"Oncolytic virus; Immunotherapy; Cancer; In vitro; Cancer immunotherapy; Cancer research; Virus; Hyperthermia; Cancer therapy; Biology; Medicine; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007987079,0.0005833883,0.0009501613,0.001097256,0.0002738433,0.001059777,0.0008279829,0.001316299,0.002473937],"category_scores_gemma":[0.0009138671,0.0002333035,0.0005281105,0.0008396611,0.0007776698,0.002043093,0.0006134593,0.003278676,0.001732262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007305653,"about_ca_system_score_gemma":0.0007013839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007044405,"about_ca_topic_score_gemma":0.001272462,"domain_scores_codex":[0.9997583,0.00006877143,0.00002457923,0.000042683,0.00007978889,0.0000259358],"domain_scores_gemma":[0.9996098,0.000222446,0.00003399443,0.00001777857,0.00008702849,0.00002913803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001154715,0.00005697797,0.0001638645,0.01025541,0.00009354153,0.00017883,0.00009612038,0.0004621675,0.003483442,0.01396312,0.05255887,0.9185721],"study_design_scores_gemma":[0.00001049102,0.00006020428,0.0002302594,0.001529059,0.00003861199,0.0005909311,0.00003079494,0.00007350491,0.0005527738,0.003107189,0.993766,0.00001018621],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001058131,0.9972005,0.0002421061,0.0007512153,0.0004968221,0.000003366832,0.00001418026,0.000009954306,0.001176065],"genre_scores_gemma":[0.001417583,0.9958953,0.0003276288,0.0007567243,0.0003719495,0.00001056549,0.00002950144,0.000004473515,0.001186293],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002473937,"threshold_uncertainty_score":0.008276165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05420414080397942,"score_gpt":0.3903414265830709,"score_spread":0.3361372857790915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}