{"id":"W4292601876","doi":"10.15252/embj.2022110777","title":"Regulation of membrane fluidity by RNF145‐triggered degradation of the lipid hydrolase ADIPOR2","year":2022,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cambridge Institute for Medical Research, University of Cambridge; Medical Research Council; Canadian Institutes of Health Research; Alzheimer Society; National Institute for Health and Care Research; NIHR Cambridge Biomedical Research Centre; Consortium canadien en neurodégénérescence associée au vieillissement; Wellcome Trust; Howard Hughes Medical Institute","keywords":"Lipotoxicity; Ubiquitin; Ubiquitin ligase; Chemistry; Cell biology; Membrane lipids; Lipid metabolism; Biochemistry; Membrane fluidity; Membrane; Phospholipid; Homeostasis; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125569,0.0002528083,0.0002096567,0.0001419398,0.0001286554,0.0004239355,0.0001360933,0.0001880768,0.0005458336],"category_scores_gemma":[0.0001248471,0.00009571418,0.0002438859,0.00009750514,0.0002054331,0.0001928763,0.0002426075,0.0002197865,0.0003192252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003670554,"about_ca_system_score_gemma":0.0001409804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006673555,"about_ca_topic_score_gemma":0.0007556443,"domain_scores_codex":[0.9998858,0.00001623001,0.00001294777,0.00003150597,0.00002942037,0.00002402409],"domain_scores_gemma":[0.9999226,0.000009308039,0.00002929856,0.00001030748,0.00001152983,0.00001689762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000488426,0.000003457049,0.0001637697,0.00000915292,0.000002133634,0.00002349643,0.000004756013,0.00002724376,0.9993279,0.0000422204,0.000009852593,0.0003372329],"study_design_scores_gemma":[0.00000332974,0.00003021834,0.004030109,0.000001981434,0.000003539146,0.0001202257,0.00001670044,0.000737646,0.9941911,0.00002028514,0.0008414518,0.000003430778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955134,0.001217113,0.002317113,0.00003975858,0.00001288818,0.000007542963,0.0002688275,0.00005597775,0.0005673543],"genre_scores_gemma":[0.9968114,0.0003795463,0.001146319,0.00002565048,0.000002583384,0.000008983869,0.0004475197,0.00001597043,0.001161955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006673555,"threshold_uncertainty_score":0.002663195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0084630347107091,"score_gpt":0.2220725934445996,"score_spread":0.2136095587338905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}