{"id":"W4292607816","doi":"10.1038/s41467-022-32275-3","title":"Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Université de Montréal; Université Laval; University of Ottawa; McGill University; University of Calgary","funders":"National Institute on Minority Health and Health Disparities; National Institute of Environmental Health Sciences; National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; Mississippi State Department of Health; Harvard Catalyst; Fondation Leducq; Broad Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Jackson State University; National Institute of General Medical Sciences; National Institute of Nursing Research; Massachusetts General Hospital; U.S. Department of Veterans Affairs; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Metabolome; Metabolite; Metabolomics; Biology; Genetics; Computational biology; Genomics; Genome-wide association study; Genotyping; Disease; Genome; Bioinformatics; Gene; Single-nucleotide polymorphism; Medicine; Genotype; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005063632,0.0003613115,0.0003098398,0.0009926099,0.0004329202,0.0004490149,0.0001558261,0.0004284393,0.001891623],"category_scores_gemma":[0.0009980216,0.000145144,0.0004877755,0.001083665,0.0001799568,0.0001421559,0.000496932,0.0003973898,0.0001639008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001366101,"about_ca_system_score_gemma":0.0002072881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002621685,"about_ca_topic_score_gemma":0.005724848,"domain_scores_codex":[0.9997762,0.00005808867,0.00001023238,0.00008786147,0.00003413408,0.00003356932],"domain_scores_gemma":[0.999561,0.0001237238,0.0001746172,0.00005563213,0.00003185336,0.00005327819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001022074,0.00009823673,0.8888842,0.00009562379,0.001334528,0.0006320652,0.0002780361,0.0005627304,0.08413333,0.0002843952,0.000581549,0.02209317],"study_design_scores_gemma":[0.00001637625,0.00008484346,0.9938847,0.0000115179,0.0002776244,0.0004969297,0.00007447203,0.0006398717,0.003504207,0.0002886768,0.0007112187,0.00000937347],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960287,0.0006864762,0.001648837,0.0001578958,0.00001033218,0.000007303237,0.0009379841,0.00004161297,0.0004810521],"genre_scores_gemma":[0.996182,0.0004032951,0.002263266,0.00007017334,0.00001728811,0.000008708624,0.0006097807,0.00001723769,0.0004282958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002621685,"threshold_uncertainty_score":0.006328046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01675877429670046,"score_gpt":0.2953721463966026,"score_spread":0.2786133720999022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}