{"id":"W4292609336","doi":"10.1093/nar/gkac704","title":"Distinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of <i>Pten</i> and in the PI3K/Akt signalling cascade","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Biology; PTEN; Polyadenylation; PI3K/AKT/mTOR pathway; Protein kinase B; Cell biology; Messenger RNA; Alternative splicing; Signalling; Computational biology; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000130453,0.0002340599,0.000162887,0.0001831522,0.0002242859,0.0004051195,0.0001601799,0.0003000134,0.0008609458],"category_scores_gemma":[0.0001838016,0.0001310323,0.0002322039,0.00009358834,0.0002624805,0.0002380085,0.0003402193,0.0003761332,0.0003882576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000327495,"about_ca_system_score_gemma":0.0001861278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004235745,"about_ca_topic_score_gemma":0.0006748799,"domain_scores_codex":[0.9997726,0.00001908095,0.00001327538,0.00008205383,0.00005856545,0.00005456417],"domain_scores_gemma":[0.9998766,0.00001350159,0.00004811939,0.00001343957,0.00001288217,0.00003543506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005185412,0.000002774057,0.000457599,0.00001278732,0.000002029516,0.0000301077,0.00001051944,0.00003304688,0.9980857,0.0002670427,0.00001925667,0.001027283],"study_design_scores_gemma":[0.00001229456,0.0001459008,0.03938517,0.00001486304,0.00001780067,0.0005356529,0.00008663296,0.001619185,0.9535983,0.0003535958,0.0042194,0.00001105502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915003,0.001838172,0.004225913,0.00007785246,0.00002562739,0.00001348117,0.0002595815,0.0000684909,0.001990535],"genre_scores_gemma":[0.9965703,0.0002586622,0.001731836,0.00007217798,0.000006430632,0.00001343048,0.0002957133,0.00002046797,0.001031001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008609458,"threshold_uncertainty_score":0.002880216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05479784924121951,"score_gpt":0.3453880647430349,"score_spread":0.2905902155018154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}