{"id":"W4292615550","doi":"10.1016/j.cll.2022.05.003","title":"Copy Number Analysis in Cancer Diagnostic Testing","year":2022,"lang":"en","type":"review","venue":"Clinics in Laboratory Medicine","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Fluorescence in situ hybridization; Computational biology; Fish <Actinopterygii>; Medicine; Biology; Bioinformatics; Oncology; Chromosome; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001029245,0.0003054575,0.001285563,0.0002577915,0.00005666883,0.000008100687,0.000339158,0.0003033047,0.001163962],"category_scores_gemma":[0.00251261,0.0002714361,0.0001572913,0.00210249,0.0001086482,0.000002927217,0.0001767511,0.0005053775,0.00001035187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001510849,"about_ca_system_score_gemma":0.000863581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001878956,"about_ca_topic_score_gemma":0.0004880732,"domain_scores_codex":[0.9975611,0.0003855341,0.001069564,0.0005346473,0.0001725049,0.0002766282],"domain_scores_gemma":[0.9980453,0.0008701123,0.0004244887,0.000498308,0.00008721107,0.0000745285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002610594,0.0004850708,0.6408754,0.007667606,0.001912851,0.0002879653,0.0004351167,0.0008466285,0.000006772513,0.0003536983,0.003896237,0.3432065],"study_design_scores_gemma":[0.0003443112,0.0000917174,0.0007910798,0.001182629,0.00106018,0.000003733974,0.0001251388,0.000007592869,0.000001217298,0.00002243726,0.996087,0.0002830148],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003566039,0.9944105,0.000007292218,0.0000267066,0.0005930461,0.0003070778,0.0002942349,0.000008255637,0.0007868428],"genre_scores_gemma":[0.002781809,0.9947736,0.00009892656,0.000221046,0.0005904158,0.000409666,0.0008508003,0.0000417665,0.0002319827],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9921907,"threshold_uncertainty_score":0.9999738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06783115621798493,"score_gpt":0.3948550410333133,"score_spread":0.3270238848153284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}