{"id":"W4292636240","doi":"10.1371/journal.pone.0273333","title":"Association of TGFB1 rs1800469 and BCMO1 rs6564851 with coronary heart disease and IL1B rs16944 with all-cause mortality in men from the Northern Ireland PRIME study","year":2022,"lang":"en","type":"article","venue":"PLoS ONE","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National de la Santé et de la Recherche Médicale; Queen's University Belfast; Queen's University; British Heart Foundation","keywords":"Medicine; Hazard ratio; Myocardial infarction; Internal medicine; Population; Proportional hazards model; Prospective cohort study; Epidemiology; Coronary artery disease; Single-nucleotide polymorphism; Cause of death; Cardiology; Confidence interval; Disease; Genotype; Environmental health; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000874025,0.0003538659,0.0004588797,0.000322725,0.0003743853,0.0004569638,0.0004166633,0.0003417799,0.001777527],"category_scores_gemma":[0.001898707,0.0003069159,0.0006492513,0.000410142,0.0002584981,0.0001544529,0.0005534163,0.0006164535,0.0002075555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002356336,"about_ca_system_score_gemma":0.0003116748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006789932,"about_ca_topic_score_gemma":0.009886224,"domain_scores_codex":[0.9995876,0.0001259177,0.00002997038,0.000136395,0.00005974618,0.00006038908],"domain_scores_gemma":[0.9990214,0.0001524546,0.0004066825,0.0001704013,0.00008952025,0.0001594777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001006351,0.00003923039,0.9954947,0.00002193913,0.0001952451,0.0002103476,0.0001452359,0.00004864737,0.0009967029,0.00002069537,0.0003650046,0.001455807],"study_design_scores_gemma":[0.000067362,0.0001118613,0.9986717,0.00000729779,0.00011956,0.0003284877,0.00009699859,0.00009115946,0.0001068061,0.00002807485,0.0003659996,0.000004779955],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998848,0.0001896386,0.0000816406,0.00004658133,0.000006913286,0.000008061073,0.0004775566,0.00000378525,0.0003379605],"genre_scores_gemma":[0.9987609,0.00006347844,0.0001779085,0.00003834574,0.00001548864,0.00002112046,0.000575789,0.000003918758,0.0003429855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006789932,"threshold_uncertainty_score":0.01350081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02148943357064003,"score_gpt":0.2319690755196053,"score_spread":0.2104796419489653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}