{"id":"W4292651767","doi":"10.1007/s00401-022-02482-9","title":"Transmission of cervid prions to humanized mice demonstrates the zoonotic potential of CWD","year":2022,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Alberta; University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; National Institutes of Health; Genome Canada; Istituto Superiore di Sanità; University of Alberta","keywords":"Chronic wasting disease; Biology; Scrapie; Virology; Transmission (telecommunications); Infectivity; Bovine spongiform encephalopathy; Feces; Tropism; Prion protein; Infectious disease (medical specialty); Disease; Zoonosis; Microbiology; Medicine; Virus; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002124167,0.0001001843,0.0001299047,0.00003068967,0.00020196,0.000007483345,0.0004131048,0.00003556313,0.0001818759],"category_scores_gemma":[0.00008450497,0.00007364998,0.0001300708,0.000126971,0.00006422777,0.000002108731,0.0002997716,0.000103071,0.000001167222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003605146,"about_ca_system_score_gemma":0.00004105765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000051944,"about_ca_topic_score_gemma":4.58196e-7,"domain_scores_codex":[0.9989657,0.0002828624,0.0002204658,0.0002413246,0.0001399344,0.0001496784],"domain_scores_gemma":[0.9994701,0.00002424873,0.0001168596,0.0002932511,0.00004129836,0.00005421218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001863301,0.00009114134,0.0001952826,0.00001325449,0.000008611318,0.0000118968,0.00005060053,0.0003233448,0.9920224,0.0000333798,0.0002027903,0.006860992],"study_design_scores_gemma":[0.000932374,0.002695944,0.03448196,0.00002055835,0.0001410014,0.0001542356,0.0004656499,0.000226268,0.9202315,0.0003296415,0.03996569,0.0003552064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968588,0.001178175,0.0006870016,0.000713934,0.00006774906,0.0002803737,0.00004570228,0.000009337895,0.0001589656],"genre_scores_gemma":[0.9986664,0.0003115658,0.0004779752,0.0004023892,0.00003037101,0.00002963117,0.00002155542,0.00001181784,0.00004829425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0717909,"threshold_uncertainty_score":0.3003359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01063432287092133,"score_gpt":0.232831305863282,"score_spread":0.2221969829923607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}