{"id":"W4292651767","doi":"10.1007/s00401-022-02482-9","title":"Transmission of cervid prions to humanized mice demonstrates the zoonotic potential of CWD","year":2022,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Alberta; University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; National Institutes of Health; Genome Canada; Istituto Superiore di Sanità; University of Alberta","keywords":"Chronic wasting disease; Biology; Scrapie; Virology; Transmission (telecommunications); Infectivity; Bovine spongiform encephalopathy; Feces; Tropism; Prion protein; Infectious disease (medical specialty); Disease; Zoonosis; Microbiology; Medicine; Virus; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003275918,0.0004928535,0.0001466037,0.0006223492,0.0001827405,0.0003154917,0.0001734828,0.0004698573,0.001367285],"category_scores_gemma":[0.0002931634,0.0001464084,0.0002485107,0.0001544093,0.0003723518,0.0002636528,0.0002875205,0.0007883403,0.0003058792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002154698,"about_ca_system_score_gemma":0.0001189494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010912,"about_ca_topic_score_gemma":0.0007742026,"domain_scores_codex":[0.999788,0.00004992743,0.00001801953,0.00006932438,0.00003528853,0.00003954929],"domain_scores_gemma":[0.9997211,0.0000744808,0.00007074657,0.00006495303,0.00002736319,0.00004125261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005157337,0.0001555128,0.005288401,0.0001192018,0.00004384784,0.0008226791,0.000167015,0.00006626366,0.9889089,0.0004168914,0.0001777988,0.003317627],"study_design_scores_gemma":[0.00008694509,0.002244629,0.0656814,0.0001548603,0.0001309339,0.01557819,0.0002989646,0.002055456,0.9041378,0.001009069,0.008594433,0.00002728399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898511,0.003385474,0.002577567,0.0001880491,0.00004114516,0.00003915199,0.0005964614,0.00006346498,0.003257446],"genre_scores_gemma":[0.9928444,0.002068236,0.002689787,0.0001399239,0.00001694676,0.00002639969,0.000700018,0.0000170498,0.001497153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001367285,"threshold_uncertainty_score":0.004574001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01063432287092133,"score_gpt":0.232831305863282,"score_spread":0.2221969829923607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}