{"id":"W4292674947","doi":"10.1016/j.cell.2022.06.048","title":"Epigenetic reader SP140 loss of function drives Crohn’s disease due to uncontrolled macrophage topoisomerases","year":2022,"lang":"en","type":"article","venue":"Cell","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Harvard Stem Cell Institute; National Institutes of Health; Canada Foundation for Innovation; University of California Berkeley; University of Massachusetts Medical School; Massachusetts Institute of Technology; National Institute of Diabetes and Digestive and Kidney Diseases; Kenneth Rainin Foundation; Massachusetts General Hospital","keywords":"Biology; Epigenetics; Immune system; Chromatin; Loss function; Bromodomain; Genetics; Cancer research; Cell biology; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002401427,0.0003417211,0.0003336746,0.000488775,0.0002687484,0.0006658098,0.0004119054,0.0009472019,0.006384681],"category_scores_gemma":[0.0004806178,0.0002996218,0.0004149766,0.0002735912,0.0008675122,0.0002523402,0.0005074638,0.001608816,0.001276305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003984238,"about_ca_system_score_gemma":0.0003467365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005022323,"about_ca_topic_score_gemma":0.0007716829,"domain_scores_codex":[0.9995437,0.00006676772,0.00004340281,0.0001145751,0.0001302121,0.0001013458],"domain_scores_gemma":[0.999604,0.0000731914,0.0001303456,0.00004809439,0.00002261725,0.0001216589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003526381,0.00007064366,0.001131945,0.00006119433,0.00002744679,0.001100705,0.00003130154,0.0001403507,0.9932899,0.0007467783,0.0003383106,0.002708843],"study_design_scores_gemma":[0.0002257644,0.000757379,0.02718803,0.00004048323,0.0001152636,0.01056264,0.0003316232,0.003213412,0.9416316,0.001167406,0.01473337,0.00003306235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908664,0.001185889,0.003007117,0.0006737279,0.0001865918,0.00002755816,0.0007289771,0.0002310116,0.003092616],"genre_scores_gemma":[0.9966459,0.0002753334,0.0007921853,0.0001315965,0.00001851172,0.00001435626,0.0002974614,0.00004051674,0.001784146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006384681,"threshold_uncertainty_score":0.02135885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01453923271229509,"score_gpt":0.268478244606234,"score_spread":0.2539390118939389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}