{"id":"W4292675393","doi":"10.1016/j.jmb.2022.167795","title":"Structural Analysis of Cholesterol Binding and Sterol Selectivity by ABCG5/G8","year":2022,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Ottawa","funders":"Argonne National Laboratory; Office of Science; Canadian Institutes of Health Research; University of Ottawa; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Sterol; ATP-binding cassette transporter; Biochemistry; ABCA1; Cholesterol; ABCG1; Biology; Binding site; Sterol regulatory element-binding protein; Chemistry; Transporter; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007499548,0.0002575945,0.0002311494,0.0001488694,0.0002719137,0.0001692871,0.0003875698,0.0002394852,0.001707307],"category_scores_gemma":[0.0001485092,0.0001003255,0.0002006867,0.0001743151,0.0001529463,0.0001662666,0.0001778611,0.0003957468,0.0002327625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004357664,"about_ca_system_score_gemma":0.0002152683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003529066,"about_ca_topic_score_gemma":0.003257275,"domain_scores_codex":[0.999939,0.0000127132,0.000003252646,0.000009292128,0.0000192121,0.00001659295],"domain_scores_gemma":[0.9999609,0.000007971526,0.000008825821,0.000002628474,0.000007808252,0.00001185457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009325016,0.000203697,0.008071699,0.0002646403,0.00008701264,0.001231717,0.0001418323,0.007802794,0.9694714,0.002207548,0.001190197,0.008394936],"study_design_scores_gemma":[0.0004846636,0.0009315087,0.04545534,0.00007530085,0.0002589839,0.001558453,0.0007381113,0.1984876,0.7325033,0.001339891,0.0180892,0.00007769604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977798,0.0006706641,0.0005453672,0.0001156374,0.000008948334,0.000007053579,0.0001360897,0.00002581308,0.0007107034],"genre_scores_gemma":[0.9978911,0.0003065743,0.0009481161,0.000048436,0.000003161685,0.000005089712,0.0003898047,0.000005693958,0.0004019677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003529066,"threshold_uncertainty_score":0.007017076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008305121652060913,"score_gpt":0.283974000300921,"score_spread":0.2756688786488601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}