{"id":"W4292682079","doi":"10.1089/hum.2022.138","title":"Immune Responses and Immunosuppressive Strategies for Adeno-Associated Virus-Based Gene Therapy for Treatment of Central Nervous System Disorders: Current Knowledge and Approaches","year":2022,"lang":"en","type":"review","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Genetic enhancement; Immune system; Adeno-associated virus; Immunology; Immunosuppression; Viral vector; Transgene; Transduction (biophysics); Medicine; Innate immune system; Vector (molecular biology); Gene delivery; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005469082,0.0007785261,0.000919948,0.001502657,0.0001995475,0.0008559419,0.0007008801,0.0009555775,0.002485767],"category_scores_gemma":[0.0004512749,0.0002142413,0.0004166653,0.00120805,0.0004256671,0.001104654,0.0004407493,0.001867548,0.001469973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004693618,"about_ca_system_score_gemma":0.0008171597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000614723,"about_ca_topic_score_gemma":0.001189005,"domain_scores_codex":[0.9998517,0.00002599051,0.00002262911,0.00002401012,0.00006148902,0.00001412316],"domain_scores_gemma":[0.9997808,0.0001158458,0.0000298119,0.000006273719,0.00004757056,0.00001976492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008106617,0.0001008925,0.000118168,0.01256463,0.0000583587,0.0001678892,0.00005435652,0.0003804388,0.004493221,0.003504437,0.01800362,0.9604729],"study_design_scores_gemma":[0.00002346217,0.00018546,0.0006216585,0.002411272,0.0001098365,0.001284143,0.00004170317,0.0001424171,0.001290844,0.001626117,0.9922435,0.00001947848],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001343651,0.9985293,0.0001873903,0.0001855516,0.0001517365,0.000005872432,0.000009787335,0.000007078245,0.0007890079],"genre_scores_gemma":[0.0005550036,0.9983699,0.0002689943,0.0001695108,0.0001188327,0.00000971261,0.00002135372,0.000001551181,0.0004851276],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002485767,"threshold_uncertainty_score":0.008315682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1314066052190861,"score_gpt":0.3768866582429878,"score_spread":0.2454800530239017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}