{"id":"W4292682079","doi":"10.1089/hum.2022.138","title":"Immune Responses and Immunosuppressive Strategies for Adeno-Associated Virus-Based Gene Therapy for Treatment of Central Nervous System Disorders: Current Knowledge and Approaches","year":2022,"lang":"en","type":"review","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Genetic enhancement; Immune system; Adeno-associated virus; Immunology; Immunosuppression; Viral vector; Transgene; Transduction (biophysics); Medicine; Innate immune system; Vector (molecular biology); Gene delivery; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005569054,0.0008980153,0.001780168,0.0002581212,0.0005541859,0.0001123929,0.0005194112,0.0003801395,0.0000242859],"category_scores_gemma":[0.0000176212,0.0007388685,0.0008497642,0.0001668775,0.0003091104,0.00001038684,0.0000944787,0.0001460482,3.644356e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002177458,"about_ca_system_score_gemma":0.0009880837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003432957,"about_ca_topic_score_gemma":0.00009965903,"domain_scores_codex":[0.9961675,0.0009711382,0.0008488656,0.001034562,0.0002335874,0.0007442991],"domain_scores_gemma":[0.9979555,0.0002742796,0.0006728372,0.0008436356,0.0001187576,0.000134969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008317956,0.001386431,0.000005924686,0.003046918,0.002190271,0.000001731032,0.0005931894,0.0000208792,0.05157595,0.00004658971,0.00006552402,0.9327486],"study_design_scores_gemma":[0.01263192,0.0402115,0.00007438369,0.0008152594,0.0005399669,0.00001748792,0.0004680816,0.00008772192,0.07399321,0.00009938095,0.8696389,0.001422201],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.108071,0.8844712,0.0001099938,0.000008544102,0.0001550636,0.005389411,0.001746764,0.00003599967,0.00001201869],"genre_scores_gemma":[0.01398077,0.9759901,0.00009794257,0.000006545995,0.0002694554,0.005183577,0.004101438,0.0002288729,0.000141314],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9313264,"threshold_uncertainty_score":0.9995062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1314066052190861,"score_gpt":0.3768866582429878,"score_spread":0.2454800530239017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}