{"id":"W4292694187","doi":"10.3390/biology11081247","title":"Thermostable and O2-Insensitive Pyruvate Decarboxylases from Thermoacidophilic Archaea Catalyzing the Production of Acetaldehyde","year":2022,"lang":"en","type":"article","venue":"Biology","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Bundesministerium für Bildung und Forschung","keywords":"Sulfolobus acidocaldarius; Sulfolobus solfataricus; Hyperthermophile; Biology; Biochemistry; Acetaldehyde; Enzyme; Fermentation; Pyruvate decarboxylase; Archaea; Ethanol; Alcohol dehydrogenase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002043707,0.000113408,0.0001526792,0.00002503586,0.0001689488,0.000003739459,0.0001389766,0.00005613912,0.00002030394],"category_scores_gemma":[0.00008284054,0.00008115819,0.00004988357,0.00007013557,0.0002498083,0.000002334803,0.0003299168,0.00009555501,9.840381e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000676871,"about_ca_system_score_gemma":0.00003880315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003632769,"about_ca_topic_score_gemma":0.00003932857,"domain_scores_codex":[0.9991285,0.0001858684,0.0001416077,0.0003112248,0.00005541007,0.0001774377],"domain_scores_gemma":[0.9995008,0.00003354425,0.0001034347,0.0003004228,0.00003470958,0.00002710629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008038356,0.00002198998,0.001464642,0.000002633303,0.00006746597,9.43327e-7,0.0003645085,0.00001940792,0.9917269,0.0002876333,0.0001951705,0.005768301],"study_design_scores_gemma":[0.0003136912,0.0002572591,0.015838,0.000004264387,0.00005051644,0.00003444726,0.0009286465,0.000034098,0.9109157,0.0007226641,0.07071681,0.0001838439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912847,0.007339404,0.00006101442,0.0003878708,0.0004191844,0.000177662,0.00008695779,0.0000085033,0.0002346745],"genre_scores_gemma":[0.9983575,0.0005577447,0.00008040447,0.0002169379,0.0002964273,0.00003922342,0.0001826252,0.00001452453,0.000254584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08081116,"threshold_uncertainty_score":0.3309535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009117940881903704,"score_gpt":0.2218647409702603,"score_spread":0.2127468000883566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}