{"id":"W4292694187","doi":"10.3390/biology11081247","title":"Thermostable and O2-Insensitive Pyruvate Decarboxylases from Thermoacidophilic Archaea Catalyzing the Production of Acetaldehyde","year":2022,"lang":"en","type":"article","venue":"Biology","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Bundesministerium für Bildung und Forschung","keywords":"Sulfolobus acidocaldarius; Sulfolobus solfataricus; Hyperthermophile; Biology; Biochemistry; Acetaldehyde; Enzyme; Fermentation; Pyruvate decarboxylase; Archaea; Ethanol; Alcohol dehydrogenase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001513075,0.0004169708,0.0002198819,0.000221178,0.0001189832,0.0003433087,0.0001406574,0.0002326629,0.000247706],"category_scores_gemma":[0.0002435006,0.0001265964,0.0002643787,0.0004200411,0.0001478173,0.000340969,0.000216739,0.0003184668,0.0001427018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001734967,"about_ca_system_score_gemma":0.0002287002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002676,"about_ca_topic_score_gemma":0.0009624409,"domain_scores_codex":[0.9998735,0.00001593249,0.00002103885,0.00002742824,0.00004201199,0.00001999176],"domain_scores_gemma":[0.9999157,0.000008959199,0.00002074219,0.000009340129,0.00002380899,0.00002144217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001595018,0.0000314748,0.002455048,0.000135944,0.00001664543,0.0002068566,0.00008353911,0.0001027618,0.9911742,0.00007063424,0.00006877628,0.005494672],"study_design_scores_gemma":[0.00003758927,0.0002847613,0.06674874,0.00004663396,0.0001169421,0.002864232,0.0005853286,0.002207167,0.9138973,0.0003776927,0.0127887,0.00004489143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932443,0.002663228,0.002900607,0.0001779627,0.00002646168,0.00002263869,0.000340734,0.0000259342,0.0005981785],"genre_scores_gemma":[0.9910691,0.0017282,0.003466573,0.00009229518,0.00001919429,0.00001940295,0.002123283,0.00001659707,0.00146531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001002676,"threshold_uncertainty_score":0.001993656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009117940881903704,"score_gpt":0.2218647409702603,"score_spread":0.2127468000883566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}