{"id":"W4292737569","doi":"10.1016/j.jaip.2022.06.036","title":"Dupilumab Is Effective in Patients With Moderate-to-Severe Uncontrolled GINA-Defined Type 2 Asthma Irrespective of an Allergic Asthma Phenotype","year":2022,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Sanofi-Aventis Deutschland; Merck Sharp and Dohme; Genentech; Shionogi; National Institutes of Health; Teva Pharmaceutical Industries; Novartis; AstraZeneca; Chiesi Farmaceutici; Schering-Plough; Merck; GlaxoSmithKline; Boehringer Ingelheim; American Lung Association","keywords":"Asthma; Exhaled nitric oxide; Medicine; Aeroallergen; Placebo; Dupilumab; Immunology; Allergy; Eosinophil; Immunoglobulin E; Benralizumab; Internal medicine; Allergic asthma; Gastroenterology; Bronchoconstriction; Allergen; Antibody; Pathology; Mepolizumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003397665,0.0003930489,0.001123458,0.0001280965,0.0002992147,0.0004426329,0.0002324806,0.0003502596,0.002456359],"category_scores_gemma":[0.0005992222,0.0001088084,0.0006758663,0.0001457618,0.0001698693,0.0003633591,0.0001411025,0.0009715229,0.0005013425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003316727,"about_ca_system_score_gemma":0.0003989939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008506946,"about_ca_topic_score_gemma":0.004011888,"domain_scores_codex":[0.9998203,0.00005459884,0.00001585201,0.00002789498,0.00002492564,0.00005650417],"domain_scores_gemma":[0.9997287,0.00007055979,0.00004963455,0.00001392724,0.00001916631,0.000117956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1772538,0.004747245,0.1479824,0.001970175,0.002834685,0.004912977,0.0002853024,0.0008789123,0.06626912,0.0007654329,0.02645314,0.5656466],"study_design_scores_gemma":[0.05632483,0.06148623,0.8143721,0.0005234588,0.002429313,0.01374856,0.0004191769,0.002767172,0.009621754,0.0007021597,0.03747656,0.0001287519],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623705,0.0196125,0.0006624298,0.001794915,0.0005130544,0.0002137269,0.0008311664,0.0002201837,0.01378163],"genre_scores_gemma":[0.9958467,0.001617479,0.0003678244,0.0007712108,0.0001368454,0.00003221332,0.0004503248,0.00001101406,0.0007664368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002456359,"threshold_uncertainty_score":0.008217394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009652066870694866,"score_gpt":0.3023929138854359,"score_spread":0.2927408470147411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}