{"id":"W4292764257","doi":"10.1016/j.synbio.2022.08.002","title":"Norditerpenoids biosynthesized by variediene synthase-associated P450 machinery along with modifications by the host cell Aspergillus oryzae","year":2022,"lang":"en","type":"article","venue":"Synthetic and Systems Biotechnology","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Key Research and Development Program of China; Natural Sciences and Engineering Research Council of Canada; Boston University; Higher Education Discipline Innovation Project; State Key Laboratory of Bioreactor Engineering; Hokkaido University; National Natural Science Foundation of China","keywords":"Aspergillus oryzae; Terpene; Heterologous expression; Terpenoid; Diterpene; Biochemistry; Enzyme; Biology; ATP synthase; Hydroxylation; Cytochrome P450; Chemistry; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009163816,0.000451336,0.0001919636,0.0001479801,0.00009355658,0.0002634693,0.0001320605,0.0001113507,0.0004174976],"category_scores_gemma":[0.000074091,0.0001050378,0.0002027833,0.0002055657,0.0001117731,0.0002780721,0.0002205761,0.0003224267,0.0003684205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000276908,"about_ca_system_score_gemma":0.0002965658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006361503,"about_ca_topic_score_gemma":0.0006229494,"domain_scores_codex":[0.9999148,0.000008517684,0.000007384761,0.00003124918,0.00002126774,0.00001684118],"domain_scores_gemma":[0.9999613,0.000003775106,0.0000106004,0.00000927823,0.000007001478,0.000008102099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001646022,0.000005895748,0.0001517907,0.00001192446,0.000002041959,0.00002855195,0.000005103921,0.00006524558,0.9984503,0.0001443332,0.000007959818,0.001110508],"study_design_scores_gemma":[0.000004434619,0.00005242446,0.002011662,0.000002533154,0.00001125552,0.0001226257,0.00001733614,0.0009706669,0.9947762,0.0001193644,0.001907984,0.000003516305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795308,0.001445243,0.01550902,0.00009472357,0.00003035127,0.00003038226,0.0004629999,0.0002434256,0.002652988],"genre_scores_gemma":[0.9867043,0.0009301718,0.00786221,0.00001777639,0.000006041443,0.00001742676,0.0008587273,0.00002993991,0.00357341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006361503,"threshold_uncertainty_score":0.002009094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004951774862193491,"score_gpt":0.1789051088227831,"score_spread":0.1739533339605896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}