{"id":"W4292764257","doi":"10.1016/j.synbio.2022.08.002","title":"Norditerpenoids biosynthesized by variediene synthase-associated P450 machinery along with modifications by the host cell Aspergillus oryzae","year":2022,"lang":"en","type":"article","venue":"Synthetic and Systems Biotechnology","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Key Research and Development Program of China; Natural Sciences and Engineering Research Council of Canada; Boston University; Higher Education Discipline Innovation Project; State Key Laboratory of Bioreactor Engineering; Hokkaido University; National Natural Science Foundation of China","keywords":"Aspergillus oryzae; Terpene; Heterologous expression; Terpenoid; Diterpene; Biochemistry; Enzyme; Biology; ATP synthase; Hydroxylation; Cytochrome P450; Chemistry; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006218501,0.0003988109,0.0004118369,0.00008118323,0.0009296304,0.00006757493,0.0006994437,0.0005092937,0.00003988539],"category_scores_gemma":[0.0001430643,0.0002856651,0.00009473678,0.0002962291,0.0005647613,0.000006205893,0.0003362408,0.0004155693,0.000006530855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005507199,"about_ca_system_score_gemma":0.00008347956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003365883,"about_ca_topic_score_gemma":0.00002827176,"domain_scores_codex":[0.9975731,0.0003500347,0.0004178341,0.0008299073,0.000284609,0.0005445391],"domain_scores_gemma":[0.9985536,0.0001462222,0.0003005359,0.0008344986,0.00005246002,0.0001126324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001380409,0.0002485378,0.0001759281,0.0000309168,0.0001619385,0.00001124456,0.00003255097,0.00001798602,0.9915102,0.0001193696,0.0069693,0.0005839598],"study_design_scores_gemma":[0.0007734579,0.0005545627,0.00007711,0.00003309501,0.0001579353,0.0005707837,0.001266836,0.0007394214,0.8731378,0.00001068146,0.1220236,0.0006546363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862989,0.005465192,0.0008529535,0.00259112,0.0001662897,0.0005571395,0.002905223,0.0001219005,0.001041246],"genre_scores_gemma":[0.9962724,0.0003483213,0.00003483,0.0001583944,0.00004534423,0.0002639069,0.0005266221,0.0000483164,0.002301796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1183724,"threshold_uncertainty_score":0.9999595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004951774862193491,"score_gpt":0.1789051088227831,"score_spread":0.1739533339605896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}