{"id":"W4292764309","doi":"10.1126/scisignal.add3535","title":"Frizzled does not get bent out of shape by Wnt","year":2022,"lang":"en","type":"letter","venue":"Science Signaling","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Frizzled; Dishevelled; Wnt signaling pathway; LRP5; LRP6; Cell biology; Phosphatidylinositol; Intracellular; Phosphorylation; DKK1; Biology; Chemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007926667,0.0004267734,0.0004023617,0.0001876907,0.001053899,0.001278343,0.0006257858,0.009203942,0.003984402],"category_scores_gemma":[0.005619488,0.0002600924,0.0004756298,0.0001252064,0.001115867,0.0009102589,0.0004658415,0.00927599,0.004590941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001933683,"about_ca_system_score_gemma":0.000705922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001872618,"about_ca_topic_score_gemma":0.00315438,"domain_scores_codex":[0.9994183,0.0001137883,0.00005679446,0.0000820382,0.0002578439,0.00007122718],"domain_scores_gemma":[0.999025,0.0004581679,0.00007632385,0.00008311229,0.0002158429,0.0001415766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000310439,0.00007249348,0.0009233769,0.00007551369,0.00003859143,0.008317314,0.00008833421,0.00009503124,0.003848969,0.007324917,0.9485587,0.03034631],"study_design_scores_gemma":[0.0001988095,0.0001294281,0.001749891,0.00007529617,0.00002800626,0.005267736,0.0001945279,0.0006808797,0.002257829,0.009097818,0.9802901,0.00002965881],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.004398998,0.003716236,0.000448733,0.9221611,0.05313197,0.00002282645,0.00007878,0.0001243759,0.01591705],"genre_scores_gemma":[0.05967015,0.005255166,0.0007563176,0.7843813,0.0668891,0.0000636203,0.0001183812,0.00007679542,0.08278923],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.009203942,"threshold_uncertainty_score":0.01402986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01392249282807505,"score_gpt":0.2518020887492978,"score_spread":0.2378795959212228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}