{"id":"W4292791533","doi":"10.1016/j.cgh.2022.07.030","title":"Genetic Diagnosis Guides Treatment of Autoimmune Enteropathy","year":2022,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université de Paris; Institut National de la Santé et de la Recherche Médicale; Assistance publique-Hôpitaux de Paris; Agence Nationale de la Recherche; Institut des maladies génétiques Imagine; Rare Disease Foundation","keywords":"Medicine; Enteropathy; Hypogammaglobulinemia; Autoimmunity; Protein losing enteropathy; Antibody; Refractory (planetary science); Immunology; Diarrhea; Biomarker; Gastroenterology; Cohort; Internal medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004046729,0.0002554428,0.0009256863,0.0001503999,0.0004195919,0.000003794522,0.0003395517,0.000215739,0.001626275],"category_scores_gemma":[0.00006555919,0.0002355658,0.0003044719,0.00008890234,0.001343779,0.00003232823,0.0003326391,0.0003588622,0.00004942281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003687012,"about_ca_system_score_gemma":0.00006114928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000170237,"about_ca_topic_score_gemma":0.00001803555,"domain_scores_codex":[0.99643,0.001318134,0.001126847,0.0005256903,0.00003689465,0.0005624386],"domain_scores_gemma":[0.9987056,0.0004252023,0.0003775289,0.0004346162,0.00004040718,0.00001663382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001340598,0.002049555,0.9631621,0.00001085422,0.000363383,0.00003546098,0.000370369,0.00001607543,0.00160136,0.0003403565,0.0004254445,0.03028442],"study_design_scores_gemma":[0.006725051,0.0141898,0.8298954,0.000007092377,0.0002156144,0.0007863155,0.0006485553,0.00004514713,0.0003774541,0.000372007,0.1465352,0.0002023781],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9660624,0.03080096,0.00008408058,0.0007814831,0.001760123,0.0002448806,0.00006050106,0.0000512519,0.0001543746],"genre_scores_gemma":[0.9957321,0.002647934,0.00006074713,0.0009124868,0.000007057173,0.0002607467,0.00006567068,0.00001794638,0.0002952829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1461097,"threshold_uncertainty_score":0.9992864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02569017249905329,"score_gpt":0.2869458196657272,"score_spread":0.2612556471666739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}