{"id":"W4292791710","doi":"10.1016/j.jbspin.2022.105448","title":"Use of the Auto-inflammatory Disease Activity Index to monitor disease activity in patients with colchicine-resistant Familial Mediterranean Fever, Mevalonate Kinase Deficiency, and TRAPS treated with canakinumab","year":2022,"lang":"en","type":"article","venue":"Joint Bone Spine","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Alberta Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine","funders":"Swedish Orphan Biovitrum; AbbVie; Sanofi; Novartis Pharma; Roche; Novartis","keywords":"Medicine; Familial Mediterranean fever; Canakinumab; Internal medicine; Disease; Colchicine; Gastroenterology; Anakinra","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001311441,0.0002622111,0.0002699296,0.0001139462,0.0002006745,0.00001832728,0.0001386022,0.00004264349,0.000009841556],"category_scores_gemma":[0.00006338168,0.0001864135,0.00007635875,0.0002843761,0.0001557128,0.00002246672,0.0002229469,0.0001859339,2.060612e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008985396,"about_ca_system_score_gemma":0.0002660255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001187387,"about_ca_topic_score_gemma":0.001137079,"domain_scores_codex":[0.9984329,0.0001652445,0.0002334502,0.0004342101,0.0004272574,0.000306885],"domain_scores_gemma":[0.9990202,0.000006770474,0.0001804041,0.0005145425,0.00008717302,0.0001908802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05048565,0.002325491,0.4813227,0.0002697966,0.0001640801,0.0001616232,0.0002995772,0.003750753,0.4520781,0.00001352523,0.0002344782,0.008894208],"study_design_scores_gemma":[0.003324738,0.001122776,0.9812762,0.00004672211,0.00006676199,8.914943e-7,0.00004850722,0.0004359013,0.01290556,0.00000206936,0.000489682,0.0002802633],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983097,0.000094829,0.00003357014,0.000250738,0.00007298848,0.0009011081,0.0003159603,0.00001119092,0.000009915883],"genre_scores_gemma":[0.9995119,0.00001029587,0.00001503659,0.00009920457,0.00002048171,0.0001122776,0.00008610522,0.0000320167,0.0001127099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4999534,"threshold_uncertainty_score":0.7601723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007965344436664879,"score_gpt":0.1995293946075613,"score_spread":0.1915640501708964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}