{"id":"W4292805223","doi":"10.1016/j.isci.2022.104992","title":"Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms","year":2022,"lang":"en","type":"article","venue":"iScience","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Mendelian randomization; Genome-wide association study; Candidate gene; Genetic association; Biology; Gene; Genetics; Bioinformatics; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003114754,0.00006090715,0.00006509675,0.00003000757,0.0002981688,0.00002946017,0.0001336069,0.00003070164,0.00001465263],"category_scores_gemma":[0.00005183761,0.00006191331,0.00003699491,0.0001058791,0.00002050729,0.00000411815,0.00007458177,0.00002886068,8.728145e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004076006,"about_ca_system_score_gemma":0.00004682499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008078903,"about_ca_topic_score_gemma":0.000002049417,"domain_scores_codex":[0.9993089,0.00004361366,0.0001170217,0.0002454285,0.0001488404,0.0001362116],"domain_scores_gemma":[0.999668,0.000008891658,0.0000881037,0.0001534756,0.00005113122,0.00003037384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002630178,0.00001846887,0.00003804689,0.000001842507,0.000007474839,2.24354e-7,0.00002990417,0.0009191466,0.9945751,0.002172157,0.0004550148,0.001756314],"study_design_scores_gemma":[0.003660396,0.0004285497,0.003154482,0.000002663425,0.00004505536,0.00001415145,0.0001590297,0.005739775,0.897199,0.006608057,0.08263345,0.0003553436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6229129,0.003633985,0.3712814,0.001086946,0.0002621264,0.0004433818,0.00004384708,0.00001196017,0.0003233731],"genre_scores_gemma":[0.993475,0.0001587583,0.004648254,0.0002433301,0.00002891775,0.0002713016,0.00003318285,0.000008776637,0.001132437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3705621,"threshold_uncertainty_score":0.2524752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005698481200356527,"score_gpt":0.219659114566344,"score_spread":0.2139606333659875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}