{"id":"W4292805223","doi":"10.1016/j.isci.2022.104992","title":"Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms","year":2022,"lang":"en","type":"article","venue":"iScience","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Mendelian randomization; Genome-wide association study; Candidate gene; Genetic association; Biology; Gene; Genetics; Bioinformatics; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001379807,0.0003010466,0.0003714554,0.001107541,0.0003908914,0.0003121048,0.0003446061,0.0003692646,0.002312286],"category_scores_gemma":[0.003440887,0.0001672596,0.0004721556,0.000903186,0.0004374599,0.0001428205,0.0003121616,0.0002896297,0.0001151363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002149714,"about_ca_system_score_gemma":0.0002588947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001944909,"about_ca_topic_score_gemma":0.002311997,"domain_scores_codex":[0.9986314,0.0005842483,0.00008319102,0.0003888533,0.0001910419,0.0001211644],"domain_scores_gemma":[0.9981194,0.001020297,0.0004672223,0.0002248222,0.00006641074,0.0001017963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002039585,0.00006191018,0.9527437,0.00006407297,0.0008113935,0.002049209,0.0002268475,0.0006928624,0.02500317,0.001554285,0.0002963216,0.01445666],"study_design_scores_gemma":[0.0001269715,0.0004029041,0.9869261,0.000011051,0.0004369374,0.004055034,0.00009449024,0.002713319,0.002937259,0.001308631,0.0009669933,0.00002037243],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964365,0.0004795841,0.002210943,0.00008562508,0.00000984702,0.00001131306,0.0001543364,0.00002376016,0.0005881024],"genre_scores_gemma":[0.9991661,0.00005481388,0.0005357032,0.00001663659,0.000009597349,0.000004147186,0.00007383791,0.000003534444,0.0001356544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002312286,"threshold_uncertainty_score":0.007735312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005698481200356527,"score_gpt":0.219659114566344,"score_spread":0.2139606333659875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}