{"id":"W4292805493","doi":"10.1016/j.redox.2022.102448","title":"Simultaneous imaging of redox states in dystrophic neurites and microglia at Aβ plaques indicate lysosome accumulation not microglia correlate with increased oxidative stress","year":2022,"lang":"en","type":"article","venue":"Redox Biology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; Alzheimer's Association","keywords":"Microglia; Oxidative stress; Neuroprotection; Neurite; Cell biology; In vivo; Chemistry; Neuroinflammation; Pathology; Neuroscience; Biology; Immunology; Medicine; Inflammation; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001731017,0.0003224113,0.0001887066,0.0003937187,0.0002138184,0.0002587245,0.0001340942,0.0003704701,0.0009825086],"category_scores_gemma":[0.00008010695,0.0002173989,0.0001898457,0.0001936209,0.0002091344,0.0002723501,0.0002524331,0.0004465973,0.0002183974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001927283,"about_ca_system_score_gemma":0.000105369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006135082,"about_ca_topic_score_gemma":0.001238616,"domain_scores_codex":[0.999917,0.000008296549,0.000007192325,0.00002368986,0.00001699073,0.00002674869],"domain_scores_gemma":[0.9999195,0.000009502335,0.00002631648,0.000005604432,0.00001445039,0.00002455053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007162145,0.000007815049,0.0005218436,0.00002823668,0.000004315715,0.00004677648,0.00003024593,0.00001305594,0.9987754,0.00002866622,0.000009442241,0.0004625781],"study_design_scores_gemma":[0.0000150431,0.0002846494,0.06183953,0.00001866195,0.00003667948,0.001035249,0.0001373494,0.001113696,0.9345307,0.0002525442,0.0007249055,0.00001100794],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922534,0.001526539,0.004840765,0.00006235614,0.00001059839,0.00001778754,0.0002943201,0.00005612356,0.0009379761],"genre_scores_gemma":[0.9834195,0.001523899,0.01203013,0.0000659123,0.00001260244,0.00007808841,0.0003368917,0.00002279211,0.00251024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009825086,"threshold_uncertainty_score":0.003286839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01611133982173636,"score_gpt":0.2602596092914999,"score_spread":0.2441482694697635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}