{"id":"W4292824619","doi":"10.1016/j.redox.2022.102424","title":"Mitochondrial and redox modifications in early stages of Huntington's disease","year":2022,"lang":"en","type":"article","venue":"Redox Biology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Child and Family Research Institute","funders":"European Regional Development Fund; Canadian Institutes of Health Research; Fundação para a Ciência e a Tecnologia; Santa Casa da Misericórdia de Lisboa; Fundação Luso-Americana para o Desenvolvimento","keywords":"Mitochondrion; In vivo; Striatum; Huntington's disease; Biology; Genetically modified mouse; Oxidative phosphorylation; Cell biology; Molecular biology; Pathology; Transgene; Biochemistry; Endocrinology; Medicine; Disease; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000590091,0.00009125635,0.0001398556,0.0001392398,0.0001246101,0.000009461898,0.0002103573,0.00002097613,0.00006644685],"category_scores_gemma":[0.0006103663,0.00009365621,0.00003616544,0.0002447154,0.0002331458,0.00003195892,0.0002118841,0.0001079641,0.000003267676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001551826,"about_ca_system_score_gemma":0.00007213527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004133029,"about_ca_topic_score_gemma":0.000005321633,"domain_scores_codex":[0.9986181,0.0004613075,0.0002044222,0.0004255078,0.000101839,0.0001888332],"domain_scores_gemma":[0.999351,0.0001924145,0.0000947945,0.0002632106,0.00001889217,0.00007969794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000740009,0.000118128,0.04673949,0.00000578244,0.000001483386,0.000003078352,0.0001430628,0.0002401576,0.9464323,0.005823665,0.00009481987,0.0003240336],"study_design_scores_gemma":[0.0009832315,0.0003757196,0.2912504,0.00000567831,0.00001874477,0.000002290745,0.0001111825,0.0002304775,0.7002103,0.003741308,0.002822649,0.0002480398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983752,0.0001024293,0.0000252172,0.0004976624,0.0002269693,0.0002555177,0.0003246467,0.00002025011,0.0001720636],"genre_scores_gemma":[0.99933,0.00004064381,0.0001229185,0.0001538262,0.00003552462,0.0001111504,0.00001052361,0.00001033279,0.000185027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.246222,"threshold_uncertainty_score":0.381919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02482167251846164,"score_gpt":0.2815715232658151,"score_spread":0.2567498507473535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}