{"id":"W4292824619","doi":"10.1016/j.redox.2022.102424","title":"Mitochondrial and redox modifications in early stages of Huntington's disease","year":2022,"lang":"en","type":"article","venue":"Redox Biology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Child and Family Research Institute","funders":"European Regional Development Fund; Canadian Institutes of Health Research; Fundação para a Ciência e a Tecnologia; Santa Casa da Misericórdia de Lisboa; Fundação Luso-Americana para o Desenvolvimento","keywords":"Mitochondrion; In vivo; Striatum; Huntington's disease; Biology; Genetically modified mouse; Oxidative phosphorylation; Cell biology; Molecular biology; Pathology; Transgene; Biochemistry; Endocrinology; Medicine; Disease; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113557,0.0002003444,0.0001460874,0.0003670669,0.0001373629,0.0002064809,0.0001223798,0.0003573949,0.000604497],"category_scores_gemma":[0.0000785922,0.0001573273,0.0001253636,0.000167156,0.0001261387,0.0002366745,0.0001768876,0.0002671505,0.0001353209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000159503,"about_ca_system_score_gemma":0.00007596682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007180442,"about_ca_topic_score_gemma":0.0008473522,"domain_scores_codex":[0.9999659,0.000004858624,0.000003841798,0.00001032058,0.000007754254,0.000007332882],"domain_scores_gemma":[0.9999403,0.000004525256,0.00002239309,0.000003140232,0.0000115434,0.00001812246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008763376,0.00005121662,0.01468291,0.00006606164,0.00002279787,0.0006698116,0.0001362076,0.00006106045,0.9802418,0.00008569018,0.00005243954,0.003053805],"study_design_scores_gemma":[0.00003494418,0.001472916,0.7796171,0.00003782463,0.00007243028,0.00396147,0.0004141863,0.0006118516,0.2113566,0.0003807386,0.002020502,0.000019501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997061,0.00199547,0.000347283,0.00001524886,0.000003507716,0.000006303613,0.0001673732,0.00001230193,0.0003915731],"genre_scores_gemma":[0.9972326,0.001260807,0.0003252247,0.00001515776,0.000004089386,0.00001019258,0.0002957151,0.000003240111,0.0008531368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007180442,"threshold_uncertainty_score":0.002022266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02482167251846164,"score_gpt":0.2815715232658151,"score_spread":0.2567498507473535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}