{"id":"W4292824750","doi":"10.1038/s41467-022-32592-7","title":"Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Parkinsonfonden; Genentech; Pfizer; Australian Government; Vetenskapsrådet; Eisai; Skånes universitetssjukhus; Marcus och Amalia Wallenbergs minnesfond; Parkinson Research Foundation; Alzheimer's Disease Neuroimaging Initiative; Knut och Alice Wallenbergs Stiftelse; Lunds Universitet; Eli Lilly and Company; Biogen","keywords":"Tau pathology; Disease; Neuroscience; Cognitive decline; Cognition; Alzheimer's disease; Cognitive impairment; Tau protein; Biomarker; Cognitive reserve; Medicine; Alzheimer's Disease Neuroimaging Initiative; Psychology; Internal medicine; Biology; Dementia; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003419982,0.0002878019,0.0003232447,0.0006787035,0.0002032577,0.000344954,0.0001214263,0.0002343172,0.00131204],"category_scores_gemma":[0.0008398931,0.0001646246,0.0001974737,0.0003100197,0.0002429883,0.0004002927,0.0002509137,0.0002722569,0.0001018034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001606236,"about_ca_system_score_gemma":0.0001099038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001517175,"about_ca_topic_score_gemma":0.003984788,"domain_scores_codex":[0.9999343,0.000009550318,0.000004288783,0.00002968432,0.0000081457,0.00001407656],"domain_scores_gemma":[0.9995254,0.00009112575,0.0002214382,0.00004696902,0.0000357034,0.00007930767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003110115,0.0002078055,0.7257509,0.0001707634,0.0004819914,0.001897654,0.001303037,0.0007179413,0.2407402,0.0004707103,0.0004546204,0.02469425],"study_design_scores_gemma":[0.00001086982,0.0001004285,0.9958786,0.000005145599,0.00004647121,0.0004586822,0.00007462619,0.0003447537,0.002629021,0.0003442954,0.0001020022,0.000005095783],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992425,0.0001387631,0.0003726319,0.00001101227,0.000002625359,0.000002607782,0.00006775988,0.000008106991,0.0001540445],"genre_scores_gemma":[0.9993514,0.00007853482,0.0002985666,0.000007740854,0.000007424632,0.000003417874,0.00009939866,0.000003801415,0.0001496863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001517175,"threshold_uncertainty_score":0.004389226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05906680068314207,"score_gpt":0.3090128735786531,"score_spread":0.2499460728955111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}