{"id":"W4292862014","doi":"10.1016/j.ebiom.2022.104206","title":"The relationship between the epigenetic aging biomarker “grimage” and lung function in both the airway and blood of people living with HIV: An observational cohort study","year":2022,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Providence Health Care; AIDS Vancouver; St. Paul's Hospital; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; British Columbia Lung Association; National Institutes of Health; Michael Smith Health Research BC; Canadian Institutes of Health Research; Mitacs; St. Paul's Foundation","keywords":"Epigenetics; Biomarker; Lung function; Medicine; Observational study; Cohort study; Human immunodeficiency virus (HIV); Cohort; Airway; Lung; Gerontology; Bioinformatics; Immunology; Internal medicine; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009650178,0.000205951,0.0003359781,0.0003805428,0.00062906,0.0006469181,0.0004622915,0.0006177112,0.001191954],"category_scores_gemma":[0.001803581,0.0003161233,0.0006047875,0.0006795825,0.0002112675,0.0004421544,0.0006114327,0.001058296,0.0002105493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003023478,"about_ca_system_score_gemma":0.0003265926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01290888,"about_ca_topic_score_gemma":0.01823517,"domain_scores_codex":[0.9995748,0.0001036264,0.00003907759,0.0001286358,0.0000709579,0.00008294339],"domain_scores_gemma":[0.9991882,0.00009610545,0.0002900028,0.0001679652,0.0001252962,0.0001322916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000290066,0.0000680825,0.9976692,0.00002012507,0.0001887422,0.00003164361,0.0000901213,0.00002058995,0.0002998831,0.00002324221,0.0001909453,0.001107316],"study_design_scores_gemma":[0.00001417516,0.0001361577,0.99897,0.000008966736,0.0001108975,0.00009970672,0.0001176416,0.0001163668,0.00007047928,0.00003097939,0.0003206391,0.000003966749],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972364,0.0003825129,0.0001842434,0.00006351939,0.00001055739,0.00002643867,0.001645132,0.000003803403,0.0004474964],"genre_scores_gemma":[0.9984412,0.0001369589,0.0001834786,0.00007492819,0.00001083067,0.00002688195,0.000789903,0.000002296376,0.0003335743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01290888,"threshold_uncertainty_score":0.02566749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02580370368695474,"score_gpt":0.2783809471974747,"score_spread":0.25257724351052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}