{"id":"W4292884011","doi":"10.2217/fon-2022-0595","title":"HERIZON-GEA-01: Zanidatamab + chemo ± tislelizumab for 1L treatment of HER2-positive gastroesophageal adenocarcinoma","year":2022,"lang":"en","type":"article","venue":"Future Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada); Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Medicine; Trastuzumab; Internal medicine; Chemotherapy; Oncology; Gastroesophageal Junction; Monoclonal antibody; Cancer; Adenocarcinoma; Antibody; Immunology; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001103118,0.000226455,0.0006778278,0.0001461192,0.0001512271,0.000005924986,0.0001551107,0.0000903848,0.001286832],"category_scores_gemma":[0.00001118133,0.0002001999,0.0002528299,0.0002269674,0.00007365236,0.00003887336,0.0001213782,0.0001470125,0.00001072798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001084303,"about_ca_system_score_gemma":0.0002627469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008684387,"about_ca_topic_score_gemma":0.00005103938,"domain_scores_codex":[0.9985757,0.00007208415,0.0003323778,0.0003863935,0.000239507,0.0003939226],"domain_scores_gemma":[0.9991966,0.00009286123,0.0001994645,0.0003402439,0.00006070356,0.0001101095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02588986,0.008106522,0.09516451,0.0007613979,0.002719479,0.003112798,0.007239022,0.00005141295,0.003787126,0.007008407,0.2307851,0.6153743],"study_design_scores_gemma":[0.02222334,0.04139117,0.1677056,0.00001471414,0.001045296,0.0004872588,0.004086863,0.00008605092,0.002263776,0.0001178523,0.7603283,0.0002498346],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8731357,0.01094708,0.002623729,0.05833946,0.008792704,0.009933133,0.001887819,0.0003838367,0.03395658],"genre_scores_gemma":[0.9849302,0.0001247513,0.005330961,0.001103621,0.001781418,0.0006220394,0.0007924488,0.000049059,0.005265516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6151245,"threshold_uncertainty_score":0.9996261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669934964258832,"score_gpt":0.2941696805263527,"score_spread":0.2774703308837643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}