{"id":"W4292954944","doi":"10.1016/s0140-6736(22)01246-6","title":"Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3–07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study","year":2022,"lang":"en","type":"article","venue":"The Lancet","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; University of Calgary; McGill University; Centre Hospitalier de l’Université de Montréal; CancerCare Manitoba; McMaster University; University of Manitoba; Juravinski Cancer Centre","funders":"Medical Research Council; KWF Kankerbestrijding; Peter MacCallum Cancer Centre; European Organisation for Research and Treatment of Cancer; National Health and Medical Research Council; Oncosuisse; Susan G. Komen","keywords":"Medicine; Ductal carcinoma; Clinical endpoint; Radiation therapy; Breast cancer; Breast-conserving surgery; Randomized controlled trial; Mastectomy; Urology; Surgery; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006332403,0.0001504589,0.0002637711,0.00005457389,0.000203167,0.0000547099,0.0003004642,0.00003664046,0.00001169238],"category_scores_gemma":[0.00009660733,0.0001051561,0.00002009138,0.0001705633,0.00004373472,0.00001647549,0.0002238149,0.0002024348,0.000002207115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009504992,"about_ca_system_score_gemma":0.00005117121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002257487,"about_ca_topic_score_gemma":0.003214242,"domain_scores_codex":[0.9985746,0.0005308061,0.0002170196,0.0003006958,0.0001703445,0.0002065722],"domain_scores_gemma":[0.9994252,0.0001190761,0.0001274462,0.0002885511,0.00002151364,0.00001823236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02154748,0.004097708,0.9427882,0.00001934129,0.0001896503,0.00003615411,0.007807589,0.0005248816,0.01049258,0.00003134121,0.0005835228,0.0118816],"study_design_scores_gemma":[0.1155631,0.0002938642,0.8765395,0.000009393439,0.00005344729,0.00002299016,0.005872759,0.0002673569,0.0007588117,0.00007432828,0.0003812033,0.0001632653],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962948,0.000963986,0.000008003948,0.0009663869,0.0002114781,0.001313643,0.0001483943,0.000004809893,0.00008848474],"genre_scores_gemma":[0.998262,0.0003068078,0.00002532878,0.000141198,0.0004591538,0.0006442036,0.0001429577,0.00001192338,0.000006411624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09401564,"threshold_uncertainty_score":0.4288141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0234534001551061,"score_gpt":0.3048677811396822,"score_spread":0.2814143809845761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}