{"id":"W4292954944","doi":"10.1016/s0140-6736(22)01246-6","title":"Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3–07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study","year":2022,"lang":"en","type":"article","venue":"The Lancet","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; University of Calgary; McGill University; Centre Hospitalier de l’Université de Montréal; CancerCare Manitoba; McMaster University; University of Manitoba; Juravinski Cancer Centre","funders":"Medical Research Council; KWF Kankerbestrijding; Peter MacCallum Cancer Centre; European Organisation for Research and Treatment of Cancer; National Health and Medical Research Council; Oncosuisse; Susan G. Komen","keywords":"Medicine; Ductal carcinoma; Clinical endpoint; Radiation therapy; Breast cancer; Breast-conserving surgery; Randomized controlled trial; Mastectomy; Urology; Surgery; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002278556,0.001457897,0.002396066,0.0006028027,0.0003595218,0.0009170434,0.001165936,0.001761625,0.005048185],"category_scores_gemma":[0.001229359,0.000659459,0.002120302,0.0005776308,0.001620838,0.0009216619,0.0004726575,0.002762109,0.0008918534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000951629,"about_ca_system_score_gemma":0.001182809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001446351,"about_ca_topic_score_gemma":0.002548474,"domain_scores_codex":[0.9991347,0.0005634633,0.00003085319,0.00008578697,0.00005763646,0.0001275385],"domain_scores_gemma":[0.999051,0.0003516656,0.000206873,0.0001089547,0.0000317193,0.0002497497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9614205,0.01352582,0.0006087076,0.0003404811,0.0005612321,0.00001740257,0.0000828736,0.0006477113,0.005076769,0.0001046802,0.0006946016,0.0169192],"study_design_scores_gemma":[0.6598737,0.3345578,0.003102144,0.00004171717,0.0004319288,0.00004169318,0.0000575164,0.0002662828,0.000778701,0.0001892616,0.0006363787,0.00002291961],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941674,0.002316514,0.0003262542,0.0002804238,0.0001434764,0.001116063,0.0005298601,0.00006891323,0.001050934],"genre_scores_gemma":[0.9869599,0.002641067,0.001544489,0.001143322,0.0003190883,0.002930204,0.001155467,0.00007512898,0.003231356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005048185,"threshold_uncertainty_score":0.01688784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0234534001551061,"score_gpt":0.3048677811396822,"score_spread":0.2814143809845761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}