{"id":"W4292999438","doi":"10.3390/genes13091522","title":"Alteration of E2F2 Expression in Governing Endothelial Cell Senescence","year":2022,"lang":"en","type":"article","venue":"Genes","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Centers for Disease Control and Prevention; National Natural Science Foundation of China; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Senescence; Biology; Cell biology; Enos; Endothelial stem cell; Cell cycle; Downregulation and upregulation; Umbilical vein; DNA damage; Gene knockdown; Cell; Cancer research; Nitric oxide; Nitric oxide synthase; Cell culture; Endocrinology; Gene; Genetics; In vitro; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001816076,0.0002216743,0.0001794366,0.0002072929,0.0001807778,0.0003188642,0.0001157563,0.0002715282,0.0008134278],"category_scores_gemma":[0.0001047413,0.00007551296,0.0001817103,0.0001692156,0.0001739056,0.0001978893,0.0001469089,0.0002943453,0.0001777394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002445362,"about_ca_system_score_gemma":0.0002124048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005419321,"about_ca_topic_score_gemma":0.0005915998,"domain_scores_codex":[0.9999132,0.00001700104,0.000009234336,0.00002151549,0.00001586852,0.00002323346],"domain_scores_gemma":[0.9999635,0.000005700839,0.000008846709,0.000005654215,0.000006911311,0.000009390556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002347102,0.00005816458,0.0008033524,0.00007055804,0.000009554723,0.0001109063,0.00002386994,0.00008463905,0.9936427,0.0003672631,0.000126713,0.004467641],"study_design_scores_gemma":[0.00004000835,0.0002999025,0.0101832,0.00001257438,0.000034592,0.0004943155,0.00004441971,0.0009483959,0.9720201,0.0001737502,0.01574056,0.000008223366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709398,0.01789827,0.006834772,0.0002318572,0.0001341995,0.00003834243,0.0004939425,0.0001010916,0.003327762],"genre_scores_gemma":[0.989783,0.004501094,0.001762797,0.00009344481,0.00002159147,0.00004117491,0.0004794912,0.0000133806,0.003303972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008134278,"threshold_uncertainty_score":0.00272119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01393531466541198,"score_gpt":0.2428104349978142,"score_spread":0.2288751203324022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}