{"id":"W4292999438","doi":"10.3390/genes13091522","title":"Alteration of E2F2 Expression in Governing Endothelial Cell Senescence","year":2022,"lang":"en","type":"article","venue":"Genes","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Centers for Disease Control and Prevention; National Natural Science Foundation of China; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Senescence; Biology; Cell biology; Enos; Endothelial stem cell; Cell cycle; Downregulation and upregulation; Umbilical vein; DNA damage; Gene knockdown; Cell; Cancer research; Nitric oxide; Nitric oxide synthase; Cell culture; Endocrinology; Gene; Genetics; In vitro; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001650913,0.00009020959,0.00018795,0.00009872549,0.00008310842,0.00000538991,0.00008744343,0.0000279799,0.0003029602],"category_scores_gemma":[0.00002675724,0.00008664823,0.00004524722,0.0001851578,0.00002542462,0.00005771316,0.00007754077,0.0001271657,0.000010479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005750268,"about_ca_system_score_gemma":0.00008554668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001130876,"about_ca_topic_score_gemma":0.00001380444,"domain_scores_codex":[0.9989903,0.00007531061,0.0002403566,0.0002041847,0.0003255303,0.0001643194],"domain_scores_gemma":[0.99959,0.00004058652,0.00009751612,0.0001961706,0.00002941254,0.00004626675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001608293,0.0001171172,0.06717552,0.00007801876,0.000002126999,0.00003477584,0.000942521,0.0003327741,0.9238806,0.00001113306,0.0002014662,0.007063114],"study_design_scores_gemma":[0.001209039,0.0001917042,0.02681734,0.0000642293,0.00001107481,0.00003117596,0.0009695594,0.0009434297,0.9563931,0.00001535128,0.01323219,0.0001218553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997219,0.001147241,0.0004266717,0.00009220985,0.0002622955,0.0001803864,0.00002942279,0.0000257774,0.0006170373],"genre_scores_gemma":[0.9977968,0.0001248886,0.001033187,0.0001790285,0.0001138314,0.00002435591,0.0000251213,0.00001305329,0.000689715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04035818,"threshold_uncertainty_score":0.3533413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01393531466541198,"score_gpt":0.2428104349978142,"score_spread":0.2288751203324022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}