{"id":"W4293009542","doi":"10.3390/cancers14174092","title":"MHC Class II Expression Influences the Composition and Distribution of Immune Cells in the Metastatic Colorectal Cancer Microenvironment","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Cancer Institute; National Institutes of Health; Memorial Sloan-Kettering Cancer Center; American Cancer Society","keywords":"Cytotoxic T cell; Stromal cell; Immune system; Tumor microenvironment; MHC class I; Colorectal cancer; Immunology; Medicine; Cancer research; Population; CD8; Granzyme B; Immune checkpoint; Major histocompatibility complex; CTL*; Biology; Cancer; Immunotherapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009195145,0.00007490999,0.00009474878,0.0002150544,0.0001056151,0.0002218361,0.00003932004,0.00007906894,0.0008433821],"category_scores_gemma":[0.0003149687,0.00005939794,0.00005090579,0.0001094377,0.0001206913,0.00007899984,0.00009523385,0.00009103223,0.0001461869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009218524,"about_ca_system_score_gemma":0.00005911844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004992937,"about_ca_topic_score_gemma":0.0006067068,"domain_scores_codex":[0.9999146,0.0000284062,0.000005718709,0.0000149852,0.0000119245,0.00002431967],"domain_scores_gemma":[0.9998785,0.00002512118,0.00003848413,0.000006184674,0.00001463526,0.00003697963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001456422,0.00005584339,0.4805463,0.00004866856,0.00003555958,0.0005327396,0.0001729612,0.0001435123,0.505474,0.00008917742,0.0001141787,0.01133071],"study_design_scores_gemma":[0.00002193187,0.0004293391,0.9715903,0.000007139172,0.00003852817,0.00160604,0.0002649899,0.0006168212,0.02461457,0.00005224577,0.0007530947,0.00000487602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995281,0.0001973345,0.0000607605,0.000005868335,0.00000108166,0.000001446554,0.00001143339,0.000001255808,0.0001928387],"genre_scores_gemma":[0.9998068,0.00006499062,0.00003501614,0.000003764195,0.000002404008,0.000001218328,0.00001528132,9.32092e-7,0.00006960007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008433821,"threshold_uncertainty_score":0.002821386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049508641426399,"score_gpt":0.2550356608792971,"score_spread":0.2445405744650331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}