{"id":"W4293022944","doi":"10.1158/1535-7163.23.4.1","title":"(−)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-XL-mediated apoptosis resistance","year":2005,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institutes of Health; University of Pittsburgh; U.S. Department of Defense","keywords":"Gossypol; Jurkat cells; Apoptosis; Mitochondrion; Transfection; Biology; Bcl-xL; Programmed cell death; Etoposide; Cytochrome c; Cell biology; Molecular biology; Cell culture; Biochemistry; T cell; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325155,0.0002505962,0.0001662508,0.0000491937,0.0001575188,0.00006163388,0.0002138291,0.0001810566,0.00004093067],"category_scores_gemma":[0.00002136334,0.0001890762,0.00009044524,0.0001701453,0.00006030852,0.000005008801,0.00007696608,0.000125132,0.00001742396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005253407,"about_ca_system_score_gemma":0.00005259681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001941039,"about_ca_topic_score_gemma":0.0001503361,"domain_scores_codex":[0.998687,0.00008881588,0.0002015708,0.0004425771,0.0002521098,0.0003278809],"domain_scores_gemma":[0.999185,0.00002719875,0.00008151818,0.0005101166,0.00007903159,0.0001171122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001512544,0.0000448938,0.00003426311,0.00001002733,0.0001128283,0.000001272899,0.0001363175,0.0002520427,0.9840571,0.0006826576,0.0007705971,0.01374677],"study_design_scores_gemma":[0.0003786145,0.0001074683,0.0004886726,0.0000296357,0.00004162737,0.000001273384,0.00002153247,0.0001577623,0.5917996,0.0001090049,0.406636,0.0002288383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9642813,0.0118077,0.005315,0.01476402,0.0004815076,0.0009477983,0.00007065538,0.0000524434,0.002279617],"genre_scores_gemma":[0.9835807,0.002463538,0.00104,0.009887593,0.0002935438,0.0001115192,0.00003771065,0.0000575168,0.002527841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4058654,"threshold_uncertainty_score":0.7710303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01390499792862549,"score_gpt":0.2572712026939176,"score_spread":0.2433662047652921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}