{"id":"W4293029330","doi":"10.3390/cancers14174079","title":"BMS-986158, a Small Molecule Inhibitor of the Bromodomain and Extraterminal Domain Proteins, in Patients with Selected Advanced Solid Tumors: Results from a Phase 1/2a Trial","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Tolerability; Dosing; Pharmacokinetics; Pharmacodynamics; Bromodomain; Adverse effect; Medicine; Pharmacology; Internal medicine; Oncology; Gastroenterology; Chemistry; Epigenetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001117514,0.0007794185,0.001157084,0.000259693,0.000204006,0.0004300515,0.0003600538,0.0005025388,0.001696352],"category_scores_gemma":[0.0004933923,0.0002041938,0.0006406546,0.0003504157,0.0003375069,0.0004589011,0.0001789476,0.001644599,0.0003703197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003849313,"about_ca_system_score_gemma":0.0005833494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004116817,"about_ca_topic_score_gemma":0.001597078,"domain_scores_codex":[0.9998178,0.00008323792,0.00001513723,0.00002498293,0.00002874777,0.00003013068],"domain_scores_gemma":[0.9996618,0.00007286307,0.00007912817,0.00001784898,0.00002420016,0.0001442217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3821108,0.03964157,0.02056289,0.002202575,0.002203539,0.000722643,0.0004105118,0.004374599,0.1236382,0.0005701829,0.009029912,0.4145327],"study_design_scores_gemma":[0.4980962,0.4305548,0.04733895,0.00009184659,0.0009099657,0.001019815,0.00009562363,0.002816329,0.009446453,0.0004691416,0.0091161,0.0000448108],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919947,0.004514765,0.0003694829,0.0003271262,0.00007209408,0.0006397012,0.0006959205,0.00007043511,0.001315712],"genre_scores_gemma":[0.9873368,0.005402479,0.00132594,0.0007475102,0.0001513383,0.0007087899,0.00270033,0.00002368112,0.001603094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001696352,"threshold_uncertainty_score":0.005910039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006068314566466413,"score_gpt":0.2245343426291893,"score_spread":0.2184660280627229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}