{"id":"W4293030509","doi":"10.3390/ijms23179530","title":"Altered Expression of TMEM43 Causes Abnormal Cardiac Structure and Function in Zebrafish","year":2022,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Cardiovascular Effects of Exercise","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft","keywords":"Zebrafish; Biology; Missense mutation; Cell biology; Myocyte; Phenotype; Cardiomyopathy; Caveolin 3; Genetics; Gene; Internal medicine; Heart failure; Signal transduction; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007109125,0.00007066764,0.0002346409,0.0004043552,0.00004298049,0.00002451695,0.0002076266,0.00002337604,0.00005757458],"category_scores_gemma":[0.0001189116,0.00005858675,0.0001666593,0.0001898942,0.0001084129,0.0001851571,0.0001361332,0.000190145,1.576724e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006238133,"about_ca_system_score_gemma":0.0001321666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003131669,"about_ca_topic_score_gemma":0.000001889962,"domain_scores_codex":[0.9981982,0.0001178889,0.0002792822,0.0001271669,0.001186497,0.00009094958],"domain_scores_gemma":[0.9994169,0.00004451547,0.0002116359,0.0000814617,0.0001919754,0.00005345445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006068822,0.00009074558,0.03847061,0.00002023253,0.0001809231,0.000405989,0.0003477591,0.005867227,0.9461657,0.000131444,0.0002001083,0.007512415],"study_design_scores_gemma":[0.003838105,0.001715117,0.3562109,0.0003652495,0.0002109637,0.002465148,0.001161392,0.0003591029,0.6305753,0.001153416,0.001734554,0.0002108017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960074,0.00229024,0.0002171568,0.0002820042,0.0009781111,0.00009384006,0.00001063921,0.000002839095,0.0001178133],"genre_scores_gemma":[0.9990469,0.00005367362,0.0006450024,0.0001276178,0.000111381,0.000002008125,0.000002869329,0.000005109363,0.000005400165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3177402,"threshold_uncertainty_score":0.2389098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007603071341726926,"score_gpt":0.2625329471063519,"score_spread":0.254929875764625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}