{"id":"W4293051847","doi":"10.1093/ecco-jcc/jjac122","title":"Corticosteroid-Sparing Effects of Filgotinib in Moderately to Severely Active Ulcerative Colitis: Data from the Phase 2b/3 SELECTION Study","year":2022,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Genentech; Dr. Falk Pharma; Baxter Healthcare Corporation; Bausch Health; Sun Pharma; Tillotts Pharma; Novo Nordisk; Kyowa Hakko Kirin; Amgen; ActoGeniX; Galápagos; Celltrion; Boston Pharmaceuticals; Glenmark Pharmaceuticals; Mitsubishi Tanabe Pharma Corporation; BeiGene; Kissei; Janssen Biotech; Teva Pharmaceutical Industries; EA Pharma Co., Ltd.; Ablynx; Gilead Sciences; Celgene; Pfizer; Biogen; GlaxoSmithKline; Allergan; AstraZeneca; Seres Therapeutics; Nichi-Iko Pharmaceutical; Akebia Therapeutics; Bristol-Myers Squibb; Eli Lilly and Company; Ironwood Pharmaceuticals, Incorporated","keywords":"Medicine; Ulcerative colitis; Colitis; Corticosteroid; Internal medicine; Gastroenterology; Selection (genetic algorithm); Machine learning","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006633615,0.0006930481,0.001390921,0.0002742303,0.0003317657,0.0006906356,0.0003963686,0.0005718365,0.00243325],"category_scores_gemma":[0.004735007,0.0002157049,0.002515233,0.0004974309,0.0004936593,0.0003761562,0.0003269525,0.001223455,0.0002686634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00044462,"about_ca_system_score_gemma":0.001133688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008659207,"about_ca_topic_score_gemma":0.002349433,"domain_scores_codex":[0.9971099,0.001944948,0.0002315967,0.000241933,0.0003175458,0.0001541141],"domain_scores_gemma":[0.9939322,0.002474986,0.001969393,0.0005143365,0.000473056,0.0006359554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8290959,0.00386597,0.04427133,0.002165892,0.01561319,0.0002000253,0.0002257369,0.001022098,0.01066747,0.0001382969,0.004804643,0.08792941],"study_design_scores_gemma":[0.5204297,0.1997595,0.2389016,0.0004144831,0.0230044,0.001248495,0.0001852364,0.001517239,0.004392707,0.0004864889,0.00957359,0.00008658971],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794959,0.01454055,0.0004968747,0.0005703437,0.00006429199,0.0007213655,0.002608533,0.0000393282,0.001462683],"genre_scores_gemma":[0.9927004,0.002687994,0.0004999888,0.0006030677,0.0001130148,0.0003352719,0.002694095,0.00001128514,0.0003549281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006633615,"threshold_uncertainty_score":0.03508228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01873039318157347,"score_gpt":0.2915927346552805,"score_spread":0.272862341473707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}