{"id":"W4293063328","doi":"10.15252/embr.202255502","title":"Identification and characterization of in vitro expanded hematopoietic stem cells","year":2022,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Vetenskapsrådet; Cambridge Institute for Medical Research, University of Cambridge; HORIZON EUROPE European Research Council; Biotechnology and Biological Sciences Research Council; Medical Research Council; Cancer Research UK; University of Cambridge; National Centre for the Replacement, Refinement and Reduction of Animals in Research; National Centre for the Replacement Refinement and Reduction of Animals in Research; Blood Cancer UK; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Wellcome Trust","keywords":"Biology; clone (Java method); Haematopoiesis; Stem cell; Gene expression profiling; Computational biology; Cell biology; Gene; Transplantation; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004109716,0.00007519114,0.0002257141,0.0001447542,0.00003917044,0.000007001228,0.00002269903,0.00003209968,0.0000888853],"category_scores_gemma":[0.000005021128,0.00008078634,0.00003051891,0.0002020469,0.0000208047,0.00005705494,0.00001928221,0.00008425748,0.000001637132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004777258,"about_ca_system_score_gemma":0.00005095623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001002542,"about_ca_topic_score_gemma":5.485433e-7,"domain_scores_codex":[0.9987425,0.00005540279,0.0005809565,0.00022274,0.0002991057,0.00009933609],"domain_scores_gemma":[0.9993782,0.00002504329,0.0002866953,0.000230776,0.00003595909,0.00004329604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006398033,0.00009576082,0.01239973,0.0003071686,0.000008330516,0.0002987344,0.001910943,0.000003997688,0.9841556,0.00002096336,0.000007782588,0.0007270355],"study_design_scores_gemma":[0.0003972776,0.00003773457,0.05066748,0.0000521164,0.00003866673,0.001505395,0.0004250235,0.0001533642,0.9464979,0.00005836519,0.0000956253,0.0000710501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984862,0.00004040522,0.0004194851,0.0001131245,0.000205071,0.0004714627,0.000007872595,0.00002496602,0.0002313651],"genre_scores_gemma":[0.9990921,0.00001880178,0.00005135606,0.00003564598,0.00001218516,0.00007269127,0.0001030145,0.00001426738,0.0005999429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03826775,"threshold_uncertainty_score":0.3294371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337006915756924,"score_gpt":0.245540310961975,"score_spread":0.2321702418044058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}