{"id":"W4293063328","doi":"10.15252/embr.202255502","title":"Identification and characterization of in vitro expanded hematopoietic stem cells","year":2022,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Vetenskapsrådet; Cambridge Institute for Medical Research, University of Cambridge; HORIZON EUROPE European Research Council; Biotechnology and Biological Sciences Research Council; Medical Research Council; Cancer Research UK; University of Cambridge; National Centre for the Replacement, Refinement and Reduction of Animals in Research; National Centre for the Replacement Refinement and Reduction of Animals in Research; Blood Cancer UK; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Wellcome Trust","keywords":"Biology; clone (Java method); Haematopoiesis; Stem cell; Gene expression profiling; Computational biology; Cell biology; Gene; Transplantation; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003497012,0.0002139691,0.0002300873,0.0004822786,0.0001338103,0.0003515453,0.0001966229,0.0002010293,0.001166943],"category_scores_gemma":[0.0003159209,0.0000889307,0.0001763907,0.0004132349,0.0001632695,0.0001011316,0.0001885976,0.0003650975,0.0006398628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000997892,"about_ca_system_score_gemma":0.0001666467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002932445,"about_ca_topic_score_gemma":0.0004469276,"domain_scores_codex":[0.9997786,0.00003485304,0.00002844212,0.00004732962,0.00008359541,0.00002724259],"domain_scores_gemma":[0.9998364,0.00005157644,0.00002019785,0.00002954293,0.00003542073,0.00002690407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002774187,0.00001189267,0.0006477977,0.00002348147,0.000003315234,0.0000521625,0.00002480136,0.0001424841,0.996551,0.00008357114,0.00004893727,0.002382696],"study_design_scores_gemma":[0.000006218557,0.000151054,0.01245436,0.00000974888,0.00002485334,0.0003224251,0.00003704822,0.001417992,0.979301,0.00008737711,0.006183009,0.0000050156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9137231,0.001676982,0.06942452,0.0001640999,0.00003739576,0.000411698,0.01015159,0.0003716624,0.004038977],"genre_scores_gemma":[0.8862911,0.002190839,0.07316291,0.0002991624,0.00004931343,0.0006111189,0.03190452,0.0001562778,0.005334675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001166943,"threshold_uncertainty_score":0.003903806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337006915756924,"score_gpt":0.245540310961975,"score_spread":0.2321702418044058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}