{"id":"W4293065290","doi":"10.1016/j.isci.2022.104972","title":"Sarco(endo)plasmic reticulum Ca2+-ATPase function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice","year":2022,"lang":"en","type":"article","venue":"iScience","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Canadian Institutes of Health Research; Brock University; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"SERCA; mdx mouse; Duchenne muscular dystrophy; Ventricle; Internal medicine; Endocrinology; Chemistry; Muscular dystrophy; Sarcolemma; Medicine; Anatomy; Skeletal muscle; ATPase; Dystrophin; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000269419,0.001025685,0.0005881002,0.001573066,0.0004437926,0.0007485906,0.0005268328,0.0009890058,0.004240757],"category_scores_gemma":[0.0002097045,0.0007149193,0.0004094417,0.0004063476,0.0006623858,0.0005186123,0.0005150714,0.001378615,0.00131782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003743586,"about_ca_system_score_gemma":0.0003004576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001647902,"about_ca_topic_score_gemma":0.002770138,"domain_scores_codex":[0.9996823,0.00001779211,0.00004900188,0.00009777946,0.00009656909,0.0000566288],"domain_scores_gemma":[0.9993204,0.00004077599,0.0002545733,0.00002488363,0.0000407763,0.0003185898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003766969,0.00005209755,0.0006443919,0.00004215373,0.00001475538,0.0001946449,0.00004123249,0.00002441337,0.9976005,0.0001286308,0.0001273883,0.0007531442],"study_design_scores_gemma":[0.0002709968,0.0007379362,0.1538569,0.0001039417,0.0002103669,0.004405723,0.0004597955,0.00106216,0.8288348,0.0004562085,0.009547884,0.00005323987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893615,0.001456988,0.002787204,0.0003683243,0.0001351224,0.00003206431,0.003600437,0.0002453389,0.002012912],"genre_scores_gemma":[0.964811,0.00196397,0.003554578,0.0003383181,0.00008671583,0.0001643048,0.004663361,0.0003958739,0.02402188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004240757,"threshold_uncertainty_score":0.01418674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005671741725867941,"score_gpt":0.2127317221171738,"score_spread":0.2070599803913059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}