{"id":"W4293065290","doi":"10.1016/j.isci.2022.104972","title":"Sarco(endo)plasmic reticulum Ca2+-ATPase function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice","year":2022,"lang":"en","type":"article","venue":"iScience","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Canadian Institutes of Health Research; Brock University; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"SERCA; mdx mouse; Duchenne muscular dystrophy; Ventricle; Internal medicine; Endocrinology; Chemistry; Muscular dystrophy; Sarcolemma; Medicine; Anatomy; Skeletal muscle; ATPase; Dystrophin; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001979638,0.0001216639,0.0001245467,0.00004698808,0.0002397601,0.00001803625,0.000182973,0.00006978132,0.00007555323],"category_scores_gemma":[0.00003949816,0.0001258712,0.00006121636,0.0001777199,0.0002096891,0.00001088358,0.00025221,0.0001465214,0.000005858653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001832365,"about_ca_system_score_gemma":0.00007092454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001235732,"about_ca_topic_score_gemma":0.0002380737,"domain_scores_codex":[0.998839,0.0001176366,0.0001400293,0.0005017393,0.0001481883,0.0002533692],"domain_scores_gemma":[0.9996079,0.00001771192,0.00005681585,0.0002341324,0.00002117914,0.00006222758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009870862,0.00006117328,0.02335929,0.000005253039,0.00001503536,0.000005984681,0.0004691011,0.00009089911,0.9692501,0.00005539289,0.001790214,0.00479883],"study_design_scores_gemma":[0.002745596,0.001558422,0.7830609,0.00002570633,0.00008413811,0.00003588048,0.007785473,0.002257854,0.158258,0.003175166,0.03979858,0.001214333],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952048,0.00343789,0.00008338115,0.0002746755,0.0003557223,0.0001269272,0.00008784032,0.00001159112,0.0004171552],"genre_scores_gemma":[0.9990556,0.0001759494,0.00005084814,0.000353933,0.00006386927,0.00004259599,0.00007941753,0.000008650161,0.0001690934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8109921,"threshold_uncertainty_score":0.5132881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005671741725867941,"score_gpt":0.2127317221171738,"score_spread":0.2070599803913059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}