{"id":"W4293072726","doi":"10.1212/wnl.0000000000201222","title":"Association Between Lysine Reduction Therapies and Cognitive Outcomes in Patients With Pyridoxine-Dependent Epilepsy","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; Western University","funders":"National Center for Advancing Translational Sciences; National Institutes of Health; European Commission; Georgia Clinical and Translational Science Alliance; Vitaflo","keywords":"Pyridoxine; Epilepsy; Medicine; Psychology; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001101124,0.0002598347,0.0004324057,0.0004329062,0.0002473298,0.000453901,0.0002958282,0.0003412724,0.0009514872],"category_scores_gemma":[0.003869285,0.000114791,0.0009063986,0.0007257357,0.000174021,0.0003088788,0.0003435233,0.000685202,0.00006990603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004568704,"about_ca_system_score_gemma":0.0004308683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003421206,"about_ca_topic_score_gemma":0.005286562,"domain_scores_codex":[0.9992936,0.0002256999,0.0001186361,0.0001219561,0.0001509963,0.00008909361],"domain_scores_gemma":[0.9973643,0.0007136897,0.001468936,0.0000934859,0.0001923166,0.0001671345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009139785,0.00007562345,0.9956893,0.00003164421,0.0003786427,0.00005340178,0.00002692762,0.00006838384,0.00009282295,0.00001306694,0.00007292438,0.002583285],"study_design_scores_gemma":[0.00005388262,0.0004108592,0.9986577,0.00001363566,0.0001943772,0.0001814232,0.0000606565,0.0002054125,0.00006103879,0.00003551714,0.0001215208,0.000003916541],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986643,0.0006877874,0.00004442208,0.00007101892,0.000005162828,0.000006366839,0.0002213008,0.000002079226,0.000297656],"genre_scores_gemma":[0.9995365,0.0001242268,0.00004318915,0.00002501144,0.000006266327,0.000007100814,0.0001897118,7.702118e-7,0.00006707178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003421206,"threshold_uncertainty_score":0.006802619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004260979922350716,"score_gpt":0.2102989871079222,"score_spread":0.2060380071855715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}