{"id":"W4293073857","doi":"10.2337/db22-183-or","title":"183-OR: Overcoming Immunological Barriers for “Off-the-Shelf” iPSC-Derived Islets","year":2022,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Induced pluripotent stem cell; Immune system; Transplantation; Medicine; Immunology; Internal medicine; Biology; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004274385,0.0003865724,0.0003225973,0.0001883183,0.0001667838,0.0007375557,0.0004889924,0.0005139506,0.005097985],"category_scores_gemma":[0.0002354465,0.000154661,0.0003300237,0.0001360563,0.0002310546,0.0005100784,0.0006098921,0.0009150822,0.001854982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002034479,"about_ca_system_score_gemma":0.0002320815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001211161,"about_ca_topic_score_gemma":0.0001842111,"domain_scores_codex":[0.9996183,0.00005074434,0.00002865435,0.00006352832,0.0001679645,0.00007078896],"domain_scores_gemma":[0.9998763,0.00002481172,0.00003370685,0.00003033601,0.00001849183,0.00001637894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008109405,0.00004188892,0.0001636963,0.0001657864,0.00001134441,0.0001838106,0.00003831758,0.0001724649,0.988755,0.0007234923,0.0005472818,0.009115858],"study_design_scores_gemma":[0.00002093282,0.0002026961,0.001204503,0.0000183027,0.00003456587,0.0005594249,0.00003758669,0.0009768157,0.9747063,0.0002201685,0.02201163,0.00000724205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8637217,0.00484311,0.09075953,0.0008073124,0.0006747364,0.0004698727,0.001824656,0.001571263,0.03532785],"genre_scores_gemma":[0.9353539,0.003108783,0.0271407,0.0009844257,0.0001542135,0.0003037172,0.002398824,0.0005631939,0.02999225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005097985,"threshold_uncertainty_score":0.01705444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02188889493134451,"score_gpt":0.2577891982007595,"score_spread":0.235900303269415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}