{"id":"W4293073909","doi":"10.2337/db22-77-or","title":"77-OR: Native LDL Upregulate the NLRP3 Inflammasome in Human Adipose Tissue: A Mechanism for Higher Risk for Type 2 Diabetes in Subjects with HyperapoB","year":2022,"lang":"en","type":"article","venue":"Diabetes","topic":"Cardiovascular Disease and Adiposity","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Endocrinology; Internal medicine; Inflammasome; Postprandial; Insulin resistance; Type 2 diabetes; Apolipoprotein B; White adipose tissue; Hyperinsulinemia; Adipose tissue; Medicine; Chemistry; Biology; Insulin; Diabetes mellitus; Cholesterol; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002479486,0.0002424068,0.0004082021,0.0001278701,0.0001962663,0.0003752575,0.0001214016,0.0002819161,0.003651687],"category_scores_gemma":[0.0001452873,0.0001346751,0.000245601,0.0001326792,0.000173144,0.0001986409,0.0002298253,0.000325363,0.0004169247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001201609,"about_ca_system_score_gemma":0.0001200287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002682375,"about_ca_topic_score_gemma":0.0003974428,"domain_scores_codex":[0.9998935,0.00002212416,0.00001310519,0.00002919651,0.0000185292,0.00002353668],"domain_scores_gemma":[0.9999087,0.00001245083,0.00002455092,0.00001312086,0.000008831144,0.00003236191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.05852326,0.00237246,0.2060707,0.0005583143,0.0004045383,0.001346021,0.000226294,0.0001607605,0.6911563,0.0001604464,0.0006009162,0.03842003],"study_design_scores_gemma":[0.001626432,0.01742049,0.9151539,0.00005546433,0.0003680789,0.00250629,0.0003050143,0.000516718,0.05959065,0.000319708,0.00211919,0.00001814042],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985211,0.0007508058,0.000232868,0.00004628972,0.00001400519,0.0000280371,0.000108864,0.000007818567,0.0002901034],"genre_scores_gemma":[0.9982246,0.0001729319,0.0003785436,0.0001313304,0.00002301591,0.00005290438,0.0002432748,0.000003498139,0.0007699984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003651687,"threshold_uncertainty_score":0.01221609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0155638511314855,"score_gpt":0.25896924288791,"score_spread":0.2434053917564244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}